Abstract: Objective:To investigate the effect of PESV on the expression of Bcl-2, SDF- 1 α and TGF-β 1 and the multi -plication and infiltration of leukemic cells in leukemia in mice. Methods:A total of60NOD-SCID mice were used for model establishment of human leukemia with extra-marrow infiltration. Fourty successful models were randomly divided into 4 groups, with 10in each group (high-dose group, medium-dose group, low-dose group and model group). Another 10nor-mal NOD-SCID mice of the same age were used as the blank control group. In high-, medium- and low-dose groups, the mice were injected through tail vein with PESV at1.2 mg/kg·d, 0.6 mg/ kg·d, 0.3 mg/kg·d, respectively. Mice in the model group and the blank control group received treatment of 0.9% physiological saline at0.3 mL/d. The mice were sacrificed at 35days after treatment. Elisa was used to detect Bcl-2, SDF- 1 α and TGF-β 1 in cell culture supernatant of serum and bone marrow. Results: The survival of mice in high-, medium- and low-dose groups was higher than that in the model group. Bcl- 2 and SDF-1 α expression in serum and bone marrow of the mice in high-, medium- and low-dose groups was signi fi -cantly lower than that in model group ( P<0.05). TGF-β 1 expression was higher in serum and bone marrow of the mice in high-, medium- and low-dose groups than in model group ( P<0.05). Conclusion:PESV can effectively reduce the expres-sion of Bcl- 2 and SDF-1 α in serum and bone marrow of mice wi th leukemia and enhance TGF-β 1 expression, and thus has inhibitory effect on multiplication and infiltration of leukemia cells.