吴 凯, 陈 昶, 高 文. 9 例原发性肺淋巴上皮瘤样癌分析及文献回顾[J]. 中国肿瘤临床, 2010, 37(8): 464-466. DOI: 10.3969/j.issn.1000-8179.2010.08.012
引用本文: 吴 凯, 陈 昶, 高 文. 9 例原发性肺淋巴上皮瘤样癌分析及文献回顾[J]. 中国肿瘤临床, 2010, 37(8): 464-466. DOI: 10.3969/j.issn.1000-8179.2010.08.012
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WU Kai, CHEN Chang, GAO Wen. Analysis of 9 Cases of Primary Lymphoepithelioma-like Carcinoma of the Lung and Review of Literatures[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2010, 37(8): 464-466. DOI: 10.3969/j.issn.1000-8179.2010.08.012
Citation: WU Kai, CHEN Chang, GAO Wen. Analysis of 9 Cases of Primary Lymphoepithelioma-like Carcinoma of the Lung and Review of Literatures[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2010, 37(8): 464-466. DOI: 10.3969/j.issn.1000-8179.2010.08.012
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9 例原发性肺淋巴上皮瘤样癌分析及文献回顾

Analysis of 9 Cases of Primary Lymphoepithelioma-like Carcinoma of the Lung and Review of Literatures

    摘要
  • 摘要: 目的：探讨原发性肺淋巴上皮瘤样癌（LELC）的临床病理特点、治疗方法以及预后情况。方法：总结9 例原发性肺淋巴上皮瘤样癌的临床资料；结合相关文献对原发性肺淋巴上皮瘤样癌进行回顾性分析。结果：9 例原发性肺淋巴上皮瘤样癌患者中，男5 例，女4 例，均来自我国华东地区；年龄39～75岁，中位年龄57岁。9 例患者的细胞角蛋白（CK）免疫组化染色均为阳性；原位杂交检测EBV 小RNA（EBER）的阳性率为77.8% 。9 例患者接受手术治疗，其中单纯手术6 例，手术加化疗3 例。7 例患者生存至今，最长生存时间为40个月。结论：原发性肺淋巴上皮瘤样癌与EB病毒感染有关，其对化疗较敏感，宜采用手术为主的多方法综合治疗，预后较好。

     

    Abstract: Objective:To investigate the clinicopathologic characteristics, treatment and prognosis of primary lymphoep -ithelioma-like carcinoma (LELC) of the lung. Methods:Clinical and pathological data of 9 patients with pulmonary LELC were reviewed. Pulmonary LELC was analyzed through review of literatures. Results: There were5 males and 4 females and all of them were from easten China. Patients' age was ranged from 39to 75years with a median of57years. Immuno -histochemistry showed that cytokeratin was positive in all of the9 cases. In situ hybridization showed positive expression of EBV-encoded small nuclear RNA (EBER) in 7 cases. Of the 9 LELC cases, 6 were treated with surgery and3 were treated with surgery plus postoperative chemotherapy. Seven patients were still alive and the longest survival was40months. Conclusion: Lymphoepithelioma-like carcinoma of the lung is associated with Epstein-Barr virus infection and may response to chemotherapy. Surgery-based multimodality treatment is recommended.

     

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