Abstract: Purpose: To investigate the clinical significance of ezrin and pAkt expression in human lung carcinoma, and to study the correlation between them. Methods: Ezrin and pAkt expression was detected by two-step immunohistochemi-cal staining using paraffin-embedded tumor tissues from 75lung carcinoma cases and 16normal lung cases with benign disease. Their correlation was analyzed. Results: The positive expression ratio of ezrin (77.3% ) was significantly lower in lung carcinoma tissues than in normal tissues ( 100 %) (P<0.05), and the downregulated expression of ezrin was significant -ly correlated with lymph node metastasis and distant tumor metastasis ( P<0.05). The positive expression ratio of pAkt in lung carcinoma tissues (68.0% ) was higher than in normal tissues ( 0) (P<0.05), and the upregulated expression of pAkt was significantly correlated with the differentiation of lung carcinoma and the clinical stages (P<0.05). There was no statisti-cal correlation between the expression of ezrin and pAkt ( r=- 0.137 ,P=0.236 ). Conclusion:Expression of ezrin is downregu lated in lung carcinoma. Ezrin may perform a suppressive role in tumor progression and it may play important roles in the genesis and development of lung carcinoma.Protein of ezrin may be a good target for anti-metastasis therapy. Expression of pAkt is upregulated in lung carcinoma. Overexpression of pAkt may promote the progression of human lung carcinoma. Ezrin may be an upstream regulator of AKT or may be involved in tumor growth suppression through the way of AKT indi-rectly. Otherwise Ezrin may not act via the AKT pathway.