Abstract: Objective: To investigate the epidemic status of nasopharyngeal carcinoma in high areas in Cangwu town in Guangxi by mass screening. To explore the sustainable development of massing screening for nasopharyngeal carcino -ma to improve early diagnosis and treatment. Methods:From 2007-2008，the mass screening of nasopharyngeal carcino-ma was carried out in Shiqiao town. Population archives were established and evolved during the epidemiological investiga-tion. All the cases of screening had a head and neck examination combined with indirect pharyngorhinoscopy, IgA antibod -ies to Epstein-Barr virus capsid antigen (IgA/VCA) and IgA antibodies to Epstein-Barr virus early antigen (IgA/EA) serology testing. The cases with a positive serological result and questionable examination received nasal endoscopy. Questionable pharynx nasalis tissue was collected and checked. The EpiData 3.1 database was used to track all the dates of the mass screening. Results:A total of 8458cases were screened for nasopharyngeal carcinoma. Of these,522 cases were positive for the Epstein-Barr virus IgA/VCA , and 28cases were positive for the Epstein-Barr virus IgA/EA. Nasal endoscopy was performed on 410 cases. Biopsies were collected on 45 cases. Nasopharyngeal carcinoma was found in 12 cases, of which 6 were early nasopharyngeal carcinoma. Eleven cases accepted treatment. The prevalence of nasopharyngeal carci -noma was 141 .87/10 5 . The early diagnosis rate was 50%. The treatment rate was91.6%.Conclusion:The early diagnosis and early treatment screening scheme in Cangwu county is one of the main strategies of prevention and cure for nasopha-ryngeal carcinoma. The work of mass screening for nasopharyngeal carcinoma has been shown successful and should be continued.