Abstract: Objective:To discuss the diagnosis and treatment of metastasized pancreatic tumors.Methods:A retrospec-tive analysis of 25cancer patients with pancreatic metastasis from the General Hospital of Beijing Air Force Military Area, Beijing, during a period from October 1998to August 2009, was conducted. Results:The primary tumors in our study includ-ed lung cancer (n=8), colon carcinoma ( n=5), stomach carcinoma (n= 4), carcinoma of gallbladder ( n=3), esophageal carci -noma (n=2), liver cancer ( n=1), malignant gastric stromal tumor (n= 1), and malignant fibrous histiocytoma (n=1). The medi-an interval between the diagnosis of primary tumor and pancreatic metastases was 24months (range: 0-192 months). Of the 25cases, 14were diagnosed by the ultrasonography (US)-guided percutaneous fine needle biopsy of pancreatic le-sions and 4 by an intra-operative biopsy. The other 7 cases were diagnosed by clinical features. In all patients, pancreati-co-duodenectomy and subtotal resection of transverse colon were performed in 2, resection of pancreatic body and tail and splenectomy in 2, biliary metal stent drainage in 1, radio-therapy and chemotherapy in 10, regional radiotherapy in 4, sys-tematic chemotherapy in 2. The other 4 patients died because of failure of therapy. Of all the cases, 24were followed-up. The median survival was 27months (range: 10-76months) in the surgery group, 11months (range: 2-20months) in the group with non-surgical treatment, 1.5 months (range: 0.5-6 months) in the group without treatment. Conclusions: The clini -cal manifestation of tumors with pancreatic metastases is non-specific. Surgical excision can prolong the survival time of patients.