Abstract: Objective:To investigate the chemopreventive effects of tea polyphenols in high-risk individuals of liver can -cer. Methods:In this one-year study, 130 high-risk individuals were assigned into 2 groups by randomized and double blind principle; the tea polyphenols group ( 500 mg tea polyphenols) and the placebo group. The phenotypic biomarker, AFB1-al-bumin adducts, was measured in serum samples, and collected at different time-points by RIA. Results:All serum samples were detectable in the 2 groups. In the tea polyphenols group, compared to baseline, a significant decrease of AFB1-albu-min adducts was found12months after intervention (P<0.05), while no significant change of AFB1-albumin adducts was de-tected in the placebo group. Conclusion:Tea polyphenols could reduce the exposure of aflatoxin in high-risk individuals, and consequently decrease cancer risk of individuals in this special endemic area.