Abstract: Objective: To improve diagnosis and management of patients with tumor-like heterotopic pancreas (TLHP) in the gastrointestinal tract. Methods:We reviewed the clinical data of 14cases who were admitted between 2000 and 2009. The cases were diagnosed preoperatively as having tumors in the gastrointestinal tract whereas the postoperative pathological results were confirmed as having heterotopic pancreas in the gastrointestinal tract.Results: In the patients of this group, there were 11males and 3 females, with ages ranging from 32to 67years. Eight of the cases were admitted with epigastric discomfort and the 6 others were detected with epigastric discomfortduring medical examination. Of the total 14patients, 10suffered TLHP in the stomach, 2 in the duodenum and 1 in the jejunum. In preoperative radiologic examina-tion, all cases were considered gastrointestinal stromal tumor and other malignancies except for 2 cases diagnosed or sus  pected as the heterotopic pancreas respectively in CT scan and gastroscopy. Surgery was conducted in all cases, with lo-cal resection in 8 of the cases, massive gastrectomy at distal stomach in 3, radical gastrectomy in 2 and pancreaticoduode -nectomy in 1. Postoperative follow up showed no relapse or death had occurred. Conclusion : TLHP in gastrointestinal tract is easily confused with other gastrointestinal tumors in the diagnosis because of a lack of characteristic clinical manifesta -tions and effevtive examination methods. Surgical procedure is best for successful management; it can clarify the diagnosis and prevent complications.