Abstract: Objective:To compare the clinical features and survival for patients with triple-negative (TNBC) and non-tri -ple-negative (non-TNBC) breast cancer, and analyze the prognosis of triple-negative breast cancer. Methods:The clinical data and survival status of 356 patients with TNBC treated in our hospital were collected. SPSS 13.0 software was used for statistical treatment. Chi-square test was used for the comparison of frequency data between the different groups. Ka-plan-Meier method was applied to analyze survivals. Log- Rank was used to compare curves between the different groups. Cox regression was applied for multivariate prognostic analysis. Statistical significance was considered atP<0.05. Results: Compared with non-TNBC, TNBC patients had some special features: 8.43% were below35years old ( P=0.000 ), 21.91% were of clinical stage Ⅲ(P=0.022 ), 13.91% had tumor size larger than5cm (P=0.000 ), 56.46% had positive lymph node status (P=0.017 ), and 21.35% were of histological grade Ⅲ. The 5-year disease-free and overall survival rates were signifi -cantly lower in TNBC than those in non TNBC (P=0.010 , P=0.003 ). For TNBC patients, monofactorial analysis showed clini -cal stage, tumor size and lymph node state were prognostic factors. Multivariate Cox regression analysis showed lymph node state was a prognostic factor. Conclusion:Compared with non-TNBC, TNBC correlates with younger age, larger tu-mor size, more positive axillary lymph nodes, higher histologic and pathologic grade, whose DFS and OS are lower and earlier, indicating local recurrence and distant metastasis. It is important to get the information of age, tumor type, tumor size, clinical stage and histological grade, especially the lymph nodes, to judge the prognosis.