Abstract: Objective: To assess the methods and results of nephroureterectomy combined with transurethral resec-tion of the intramural ureter and bladder cuff. Methods: Nephroureterectomy combined with transurethral resection of the in-tramural ureter bladder cuff was carried out on 22cases (13males and 9 females, aged from 46to 80years) of renal pelvic carcinoma and the patients were followed up for 5 to 56months with a mean time of31.3 months. The lower part of the ure ter was ligated first. Standard nephrectomy was performed after placement of a ureteral catheter. The lumbar ureter was re -sected and the catheter tip tied to the top of the distal portion of the ureter, which was later intussuscepted when the cathe-ter was removed. Change to lithotomy position, transurethral resection through the muscular wall and into the perivesical fat was performed around the everted ureteral orifice, and the bladder spontaneously close to an indwelling Foley catheter. Results: All of the patients were successfully treated. The mean duration of surgery was 170 minutes, and the mean blood loss was 150 mL with no complications. During the mean follow-up of 31.3 months, 5 patients (22.7%) experienced recur-rence of bladder tumors, but no renal fossa recurrence, and no distant metastases. Conclusion:This study confirms that nephroureterectomy combined with transurethral resection of the intramural ureter and bladder cuff is a safe, simple, radi-cal and valid procedure and is worth being applied more extensively.