Abstract: Objective:To discuss the clinical experience after video-assisted thoracic surgery (VATS) lobectomy for ear -ly stage lung cancer treated in the first VATS phase. Methods:From June 2008 to December 2009, researchers proposed VATS for56 major pulmonary resections. The clinical information was collected and the relationship between learning curve and surgery effectiveness was analyzed.Results: This study successfully performed VATS procedure for 56patients who were diagnosed as having lung cancer. There was no mortality. The incidence rate of major complications such as atel-ectasis, pulmonary embolism, atrial fibrillation, heart failure, incision infection, pulmonary infection, and air leak prolonged (> 5d) was 0, 0, 0, 3.85%,7.69%,7.69% and 23.08%, respectively, in group A and 0, 0, 0, 0, 0, 3.33%,13.33%, respectively, in group B. There were significant deviations ( P<0.05) between group A and B such as blood loss (ml), operative time (min), the group number of lymphonodes, hospital stay (d), postoperative chest tube drainage (d) and cost ( ￥100 ,000 ), but no significant deviation in quantity of single use apparatus and length of chief incision ( P>0.05). Conclusion:VATS lobecto-my is a safe and effective approach. In the first phase, expert telescope skill is an antecedent need, accurate position of the incision and clear psychological diathesis is very important, advisable potency ratio will be accepted by the patients.