Abstract: Objective:To investigate the expression of raf kinase inhibi tor protein (RKIP) and NF-κ B in lung carcinoma and its correlation with clinicopathologic features and survival time. Methods:RKIP and NF-κ B protein levels were detected using immunohistochemistry in 83lung carcinoma specimens and 65non-tumor lung samples.Results: Immunohistochem-istry revealed that of the 83carcinoma cases, there was low expression of RKIP and high expression of NF-κ B protein, 20.5% (17/83) and 68.7% (57/83), respectively. Expression levels of RKIP and NF-κ B protein were correlated wi th tumor differentiation, TNM staging, lymph node metastasis, and survival time (P<0.05, P<0.05, P<0.05, P<0.05, respectively). RKIP expression was negatively correlated wi th NF-κ B expression in lung carcinoma (P<0.05). The mean survival time in cases with a low expression level of RKIP protein was significantly shorter than those with a high expression level, whereas the mean survival time in cases wi th a high expression level of NF-κ B protein was signi ficantly shorter than those wi th a low expression level ( P<0.05). Conclusion: Expression of RKIP and NF-κ B are closely correlated wi th invasion and metastasis of lung carcinoma. RKIP may be a lung carcinoma metastasis suppressor, and decreased RKIP expression is associated wi th the increased metastatic potential of lung carcinoma cel ls through the activation of the NF-κB signal ing pathway.