Abstract:
Objective:To investigate the high-risk factors of pelvic nodal metastasis in endometrial carcinoma and to an -alyze the pelvic nodal metastasis in the carcinoma. Methods:Data of189 patients with endometrial carcinoma admitted to the Third Affiliated Hospital, the Second Affiliated Hospital and Tumor Hospital of SUN Yat-sen University, during a period from December 2000to December 2004, were retrospectively analyzed. The correlation of the pelvic lymph-node metasta -sis with age, pathological types, histological grading, muscular invasion depth and adnexal metastasis were studied. Results: The rates of pelvic nodal metastasis were 13.1%,44.4% and 8.3%, respectively, in the cases with endometrial adeno-carcinoma, adenosquamous carcinoma and non-endometrioid adenocarcinoma, and there were significant differences in the metastatic rates among the three postoperative pathologic types ( P<0.05). The rates of pelvic nodal metastasis were 2.3%,14.2% and 31.3%, respectively, in the metastases with histological grade 1, 2 and 3, with significant differences in the nodal metastases among the three histological grades ( P<0.01). The rates of pelvic nodal metastasis were 0%,8.0% and 35.4%, respectively, in the cases without muscular infiltration, with superficial invasion of the muscular layer and with deep infiltration of muscular layer. There were statistically significant differences among the three metastatic rates ( P<0.01). The rates of pelvic lymphatic metastasis were 51.5% and 6.4% in the cases with and without adnexal metastasis, respec -tively, with significant differences between the two (P<0.001 ). Logistic regression model was used for multivariate analysis of the variances which are meaningful to the univariate analysis. The results have shown that there is statistical signifi-cance in the differences of the depth of muscular infiltration and with or without adnexal metastasis (P< 0.01). Conclusion: The high-risk factors of pelvic lymph node metastasis in endometrial carcinoma include adenosquamous carcinoma, poor histological differentiation, deep infiltration of the muscular layer and adnexal metastasis. The independent high-risk factors affecting the pelvic nodal metastasis are the depth of muscular invasion and the presence or absence of the adnexal me-tastasis.