Abstract: Objective: To evaluate the feasibility and curative effect of preoperative concurrent chemoradiotherapy on locally advanced cervical cancer. Methods:From November1995to December 2008, 259 patients with stage ⅠB2- ⅡB cer-vical cancer from the Cancer Hospital of the Medical College of Shantou University with local lesions averaging >4 cm in di-ameter were enrolled and randomly divided into three groups. The preoperative concurrent chemoradiotherapy group in-cluded 64participants, the preoperative radiotherapy group had 73participants and the surgery alone group included 122 participants. The tumor volume reduction, adverse effects, pathological features, and survival rates were compared among the groups. Results:The tumor volume reduction in the preoperative concurrent chemoradiotherapy group after chemoradio-therapy was more significant ( P<0.05) than that in the preoperative radiotherapy group after radiotherapy. There was no sig -nificant difference in adverse effects between those two groups (P> 0.05). Pathology studies showed that the group with preoperative concurrent chemoradiotherapy had less infiltration of the cervix than the group with preoperative radiotherapy alone and the group with surgery alone (P<0.05). The group with preoperative concurrent chemoradiotherapy had fewer in-stances of vascular thrombosis than the group with preoperative radiotherapy alone and the group with surgery alone, with a significant difference ( P<0.05). Parametrium infiltration, vaginal infiltration and lymph node metastasis rates were similar among the 3 groups ( P>0.05). Survival analysis for the three groups at 1, 3, and 5 years after treatment were similar, with-out a significant difference (P>0.05). Conclusion:The patients with locally advanced cervical cancer treated with preopera-tive concurrent chemoradiotherapy had more reduction in tumor size than those who did not receive such treatment. Pre -operative concurrent chemoradiotherapy can be considered safe, feasible, and worthy of further study.