G-CSF 在妇科恶性肿瘤化疗后应用时机的临床观察

姜 丽; 金海红; 王智文; 孟 津

doi:10.3969/j.issn.1000-8179.2010.21.013

G-CSF 在妇科恶性肿瘤化疗后应用时机的临床观察

Clinical Observation of the Effects of G-CSF Application after Chemotherapy in the Treatment of Gynecological Tumors

摘要

摘要: 目的：探讨G-CSF 在妇科恶性肿瘤化疗后的应用时机。方法：将63例妇科恶性肿瘤患者随机分为2 组：治疗组，32例，在每次化疗后出现Ⅱ度骨髓抑制后开始给予G-CSF 预防量对症处理，150 μ g/d，皮下注射，当出现Ⅲ度骨髓抑制后，给予G-CSF 治疗量对症处理，300 μ g/d，皮下注射；对照组，31例，在每次化疗后出现Ⅲ度骨髓抑制后开始给予G-CSF 治疗量对症处理，300 μ g/d，皮下注射。两组每日复查血常规，白细胞总数2 次超过10× 10⁹/L ，停药继续观察血常规。结果：治疗组出现严重骨髓抑制少于对照组，治疗组白细胞恢复时间短于对照组，两组有统计学意义（P<0.05）。结论：化疗后出现Ⅱ度骨髓抑制后及时给予G-CSF 是化疗后预防严重骨髓抑制的一种安全、有效的方法，同时可以减少患者的经济负担。

Abstract: Objective: To investigate the effect of G-CSF application after chemotherapy on gynecological tumors. Methods:Sixty-three patients with confirmed gynecological tumors were enrolled in this study. The patients were random-ized into 2 groups: the treatment group (n=32) received a preventive dose of 150 μ g/d, IH G-CSF before II degree arrest of bone marrow and a therapeutic dose of 150 μ g/d, IH G-CSF after Ⅱdegree arrest of bone marrow and the control group re-ceived therapeutic doses of 300 μ g/d, IH G-CSF after Ⅲdegree arrest of bone marrow. Results: The treatment group had a lower rate of serious bone marrow arrest and a shorter time for WBC recovery than the control group. These differences were significant (P<0.05). Conclusion:Applying G-CSF promptly after Ⅱdegree bone marrow arrest plays a significant role in preventing serious bone marrow arrest.

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