Abstract: Objective: To investigate the relationship of four known single nucleotide polymorphisms (SNPs) of the TJP 1 gene with susceptibility and prognosis of gastric carcinoma in a Fujian Chinese Han cohort. Methods:TJP 1 gene 4 SNP loci genotypes of 200 healthy people and 220 gastric carcinoma patients were assayed using PCR-based LDR analy-sis. Results: The frequency of rare allele C in the TJP1 SNP rs7179270 locus was 0.2, while the frequency of rare allele in the other three SNP loci (rs 34771010, rs 28578444, rs 41280058) was 0.0. The frequencies of C and T alleles and CC, CT, TT genotypes at the TJP 1 rs 7179270 locus were significantly different between patients with gastric carcinoma and the con -trol groups (OR= 1.953 , 95% CI1.425 -2.677 , P<0.001 ). These frequencies were not significantly related to sex, age, degree of differentiation, depth of invasion, lymph node metastasis or survival in patients with gastric carcinoma (P>0.05). Conclusion:Individuals with CC and CT genotypes at the TJP 1 rs 7179270 locus have increased risk of gastric carcinoma, suggest -ing that screening for this genotype would be helpful in assessing the genetic susceptibility of gastric carcinoma. The fre -quency of these genotypes is not significantly related to clinicopathologic parameters or survival in gastric carcinomas, sug-gesting that TJP1 rs 7179270 polymorphism may not be involved in the progress and prognosis of gastric carcinoma.