Abstract: Objective:The characteristics of male breast cancer (MBC), which is a rare disease, are different between Western and Eastern people. Up until now almost all the information about Chinese MBC has been based on small sam-ples. The aim of this study is to explore the characteristics of Chinese MBC based on a relatively larger sample. Methods: Clinical data of 72patients with MBC, who were histopathologically confirmed and treated at the Cancer Center of Sun Yat-sen University between January1969and March 2009, were collected. The clinicopathologic features, locoregional re-currence rate, metastatic rate, and 5-year survival rate were retrospectively analyzed. Results: Infiltrating ductal carcinoma was the predominant pathological subtype, accounting for81.9%. The positive rates of ER, PR, and HER-2 were90.9%, 84.8%, and3.3%, respectively. Mass in the breast was the major initial sign in 98.5% patients and was mainly located in the areola area, accounting for 69.8%. About67.6% patients received radical mastectomy, 22.1% received modified radical mastectomy; 50% received adjuvant chemotherapy, 15.3% received neoadjuvant therapy; 19.4% patients received adju-vant radiotherapy, and44.4% received endocrine therapy. The 5-year overall survival rate of the whole group was 72.4%. The 5-year overall survival rates for stage Ⅰ, Ⅱ, Ⅲ, and Ⅳwere100 %,74.2%,57.2%, and0, respectively. About 12.5% of patients suffered locoregional recurrence at 12months, and 12.5% of patients had distant metastasis at 14months. Conclusion: The characteristics of Chinese MBC include a predominant pathological subtype of infiltrating ductal carcinoma, higher expression rate of ER and PR and lower expression rate of HER-2. Comprehensive treatment with primary surgery integrated with chemotherapy, radiotherapy or endocrine therapy provides a better prognosis.