Abstract: Objective:To improve accuracy in the diagnosis of prostate cancer arising from the base of the prostate, dif -ferentiate it from bladder cancer located at the bladder neck and standardize the diagnosis of prostate cancer. Methods:Da-ta from 12 patients with prostate cancer who were previously misdiagnosed as having bladder cancer in the hospital's out-patient department between April 2003 and April 2010 were retrospectively reviewed. Results: The average age of the patients was 70.5 ± 7.8 years. Average PSA (prostate-specific antigen) value was43.62ng/mL. All 12patients underwent digital rectal examination (DRE). Five patients had hard prostate tissue and 7 had tough prostate tissue by palpation. Pros -tate enlargement was Ⅱ° in 4 patients, Ⅲ° in 5 patients and the rest were of normal size. Nine patients had MRI examina -tion. According to the MRI, 8 cases were diagnosed with prostate cancer invading the bladder and1 case was diagnosed with prostate cancer. The twelve patients were finally confirmed as having prostate cancer by prostate biopsies ( 6-pin meth-od), Gleason 7-8 points. Clinical stage was of T4N1M1b in 7 cases and T 4N0M0 in 5 cases. Conclusion:Multi-dimensional and multi-facet imaging studies focus on the structure of the prostate, the symmetry of the prostate, the integrity of the prostate capsule, and the continuity of the bladder wall; combining this information with PSA, DRE and prostate biopsy will help to differentiate between prostate cancers arising from the base of the prostate and bladder cancer.