Abstract: Objective: The aim of this study is to identify the predictive risk factors related to postoperative complica -tions in patients undergoing laparoscopy-assisted colorectal cancer surgery. Furthermore, this analysis has provided the necessary basis for the prevention and minimization of postoperative complications. Methods:Data of165 colorectal can-cer patients who received laparoscopy-assisted surgery in our hospital, during a period from January 2007 to September 2009, were enrolled in this study. Information about the patients was collected from the case files to set up the database where the clinical factors, such as gender, age, complications, American Society of Anesthesiologists grading (ASA), histo-ry of surgery over abdominal region, TNM staging, time of surgery, intraoperative blood loss and converted to open proce -dure, were retrieved for analysis. The following postoperative complications, such as stomal leak, bowel obstruction, inci-sional hernia, deep vein thrombosis, postoperative bleeding, pneumonia, hypoproteinemia, wound infection and wound de-hiscence were also included. SPSS17.0 software for windows was used for univariate (Chi-square test and log-likelihood ratio test) and multivariate logistic regression analysis, in order to find the relevant risk factors of post-operative complica -tions. Results: Univariate analysis showed that pulmonary disease ( P=0.046 ) and the time of surgery ≥180 minutes (P=0.034 ) were related with postoperative complications of laparoscopy-assisted colorectal cancer surgery. Multivariate analy -sis indicated that pulmonary disease adjusted odds ratio (OR):4.474 , 95% confidence interval (CI)1.282 ～15.617 and the time of surgery adjusted odds ratio (OR): 5.018 , 95% confidence interval (CI) 1.592 ～15.815 were the main independent risk factors which may affect the occurrence of complications after the surgery. ConclusionsConcurrent pulmonary diseases and time of surgery are the independent risk factors of the complications for laparoscopic surgery of colorectal cancer. Lap-aroscopic assisted colorectal surgery requires strict pre-operative evaluation and appropriate case selection in order to im-prove the tolerance of patients for pneumoperitoneum and surgery. Decisive conversion to open surgery is needed for diffi-cult laparoscopic-surgery cases. Only when the surgeon with experience in laparoscopic surgery is chosen for conducting the operation, in order to shorten the time of surgery, can satisfactory clinical outcomes be achieved.