Abstract:
Intraductal papillary mucinous neoplasm (IPMN) is a spectrum of neoplasia in the pancreatic duct epitheli -um, which originates from papillary proliferations of mucin-producing epithelial cells with excessive mucus production. Com-pared with conventional pancreatic carcinoma, IPMNs are characterized by low malignancy, slow progression, rarely inva-sion of surrounding structures, low rate of lymph nodes metastasis as well as recurrence. According to the site of involve-ment IPMNs are classified into three categories, i.e., main duct type, branch duct type, and mixed type. Most branch duct IPMNs are benign, whereas the other two types are often malignant. The clinic presentation of IPMN varies and non-specif -ic. Often the diagnosis is incidental, multiple radiological approaches can display diffusive or segmental dilatation of main pancreatic duct and cystic dilatation of branch ducts. Through enlarged papilla, ERCP sampling of mucin, pancreatic juice, pancreatic duct wall and mural nodules for biopsy can help diagnosis. Treatment options for patients with IPMN range from observation to pancreatic resection depending on the natural history of the lesion. Complete resection is sufficient for be-nign and noninvasive malignant IPMNs. Malignant IPMNs acquiring aggressive treatment after parenchymal invasion ne-cessitate adequate lymph node dissection. On the other hand, asymptomatic branch duct IPMNs, in the absence of symp-toms, mural nodules, positive cytology, or cyst size less than 30mm, can be observed without resection for a considerably long time. Main duct and mixed type IPMN carry a significant risk of malignancy, and surgery is recommended regardless of the presence of symptoms. When operation is indicated, targeted pancreatic resection with frozen-section analysis of margins is recommended. Pancreatoduodenectomy or distal pacreatectomy is appropriate for the majority. Only in a small number of patients is the disease so diffuse at presentation that total pancreatectomy is necessary. IPMNs have a high sur-gical resection rate and the prognosis is favorable. In this article, we reviewed the clinic presentation, classification, patho-logical features, radiological diagnosis, and treatment of IPMNs