Abstract: Objective:To study the epidemiologic features, methods of diagnosis and treatment, and progress of bone metastasis.Methods:Two hundred and ninety-five cases with a clinical diagnosis of metastatic bone tumor admitted from 2004to 2009were reviewed. The Karnofsky scoring system for quality of life and VAS pain assessment score were applied to patients before and after treatment, and the results were analyzed. Results: Among the295 patients included in the study, 184 were male, and 111 were female. Their ages ranged from 13to 86years with an average of 56.9 years. The pri-mary malignant tumors were lung cancer, cancer of unknown origin, liver cancer, gastrointestinal cancer, breast cancer, thy-roid cancer and prostate cancer, in the order of incidence. The most frequently involved bones were spine, pelvis, proximal limb, rib and skull. Fifty two patients had solitary metastasis and 243 had multiple metastases. One hundred and nine pa-tients underwent surgical and other treatments, including chemotherapy, radiotherapy, hormone therapy, diphosphate thera -py, analgesic therapy, or a combination of these treatments. Pain relief and life quality improvement were achieved in most of the patients after treatment. Before and after therapy, respectively, the average Karnofsky score was 50and 70, and the pain VAS score was 5.6 and 2.7, with an effective rate of 63.8%.Conclusion:Metastatic bone tumor should be treated as a systemic disease. To obtain a favorable clinical outcome of metastatic bone tumor, positive management with appropriate disease evaluation and a personalized regimen are necessary.