Abstract: Objective:To assess the effect of simplifying surgical processes, shortening the period of perfusion and in -creasing surgical safety for the improved hyperthermic isolated limb perfusion (HILP) technique. Methods:Ninety-seven pa-tients with malignant tumor ( 71with malignant melanoma, 18with soft tissue sarcoma and 8 with bone sarcoma) of an ex -tremity underwent HILP. Sixteen patients were treated with standard HILP and 81 patients were treated with improved HILP. This method included changing the way for inserting cannulas, adding a drug for blood vessel dilatation in the perfus-ate and measuring the temperature of limb muscles. Results: Fifty-four patients were followed-up for 6 months to8 years. All tumors became small and soft after HILP. Tumor resection was performed at15to 25days after perfusion. Complete his-topathological response of tumor was evident in 23cases, partial histopathological response was evident in52cases and no histopathological response was evident in22cases. In the group that received improved HILP, no fascial compartment syndrome occurred (3 cases in the standard HILP group), the perfusion speed was increased, and limb swelling was mod-erate. Conclusion:Inserting cannulas into the femoral vein or axillary vein from the amputation stump of the long saphe-nous vein or cephalic vein made the procedure easier and there was no obstruction of blood or backflow that occurred. Expanding the vessel of the limb being perfused can increase the infusion speed to achieve hyperthermia ( 41℃～42℃) earli -er. Measuring the temperature of limb muscles and maintaining a temperature below43°C may prevent the occurrence of fascial compartment syndrome.