Abstract: Objective: To explore the effects and side effects of intraperitoneal hyperthermal chemotherapy combined with intravenous chemotherapy in the treatment of advanced ovarian carcinoma. Methods:Ninety patients with advanced ovarian carcinoma were selected and divided randomly into two groups. There were50cases in the treatment group, re -ceiving intraperitoneal hyperthermal chemotherapy with DDP and intravenous chemotherapy with PTX. There were 40 cases in the control group, receiving intravenous chemotherapy with PTX and DDP. The tumortumor control rate, the ascites control rate and the main side effects were observed in the two groups. Results: The control rate was72% in the treatment group and 47.5% in the control group, with a significant difference between the two groups (P = 0.018 ). The ascites control rate was 80% in the treatment group and50% in the control group, with a significant difference between the two groups (P = 0.014 ). The rates of the main side effects in the two groups were 38% and 40%, respectively, without significant differ-ences (P = 0.847 ). Conclusion:The effect of intraperitoneal hyperthermal chemotherapy combined with intravenous chemo-therapy on advanced ovarian carcinoma is better than that of intravenous chemotherapy alone and the main side effects are tolerable.