Abstract: Objective:To evaluate the efficacy and toxicity of neoadjuvant chemotherapy for cervical cancer. Methods: From 1985 to 2006, 330 patients with stage Ib-IV cervical cancers were managed into six groups (three pairs). Pair one: NS (NACT followed by surgery) compared with S (Surgery alone); Pair two: NSR (NACT followed by surgery and adjuvant radiotherapy) compared with SR (Surgery followed by adjuvant radiotherapy); Pair three: NR (NACT followed by radical ra -diotherapy) compared to R (Radical radiotherapy alone). Results: Overall effective rate of NACT was70%. Pair one: The pa-tient survival rates at 1, 3, and 5 years were 87% ,81% , and81% (NS) versus 97% ,93% and 93% (S), respectively ( P > 0.05). Pair two: The patient survival rates at 1, 3, and 5 years were 100 %,93%, and93% (NSR) versus100 %,100 % and 92% (SR), respectively (P > 0.05). Pair three: The patient survival rates at 1, 3, and 5 years were 76%,45%, and36% (NR) versus 81% ,54% and 34% (R), respectively (P > 0.05). No significant differences were found in survival curves among these three pairs. The most common adverse reactions were gastrointestinal reactions. Conclusion:NACT is effective for cervical cancer but with no benefit for overall survival.