Abstract:
To investigate the clinicopathologic features, prognosis, and influencing factors of invasive cervical adenocarcinoma. Methods: Clinical and pathologic data of 144 cases of invasive cervical adenocarcinoma treated in Tianjin Medical University Cancer Institute and Hospital between 1995 and 2004 were retrospectively analyzed. Results: The overall 5-year survival rate was 59.0%, The overall survival rates of patients with stage I, II, III, and IV were 80.1%, 59.7%, 6.3%, and 0, respectively. Univariate analysis demonstrated that the patients suffered from non-exogenic tumors, with diameters exceeding 4 cm and advanced clinical stages. The pathologic diagnosis indicated that the tumors were mucinous adenocarcinoma and clear cell carcinoma, and the patients with poorly differentiated tumor had poorer prognoses. For the 105 patients who underwent surgery, poorer prognoses were seen in those with lymph node metastasis and deep myometrial invasion. Multivariate analysis showed that the shape of tumor, clinical stage, myometrial invasion, and nodal metastasis were independent prognosis-related factors. Conclusion: Early diagnosis and individualized combination therapy are extremely important for improving the survival rate of cervical adenocarcinoma. Adjuvant radiotherapy and chemotherapy should be recommended for patients with high-risk prognostic factors, and the ovary should be reserved for young women with early cervical adenocarcinoma.