Abstract: To evaluate clinical effect of cisplatin-iodized oil suspension emulsions in lingual arterial chemoembolization on tongue cancer in advanced stages. Methods: A total of 29 patients with squamous cell carcinoma of the tongue of T3 or T4 stage were randomized into two groups. In the Group A ( 14 cases ), ultraselective intralingual-arterial infusion of cisplatin and iodinated oil resuspending mixture was conducted under guidance of preoperative DSA scan. In Group B ( 15 cases ), intravenous drip infusion of cisplatin was performed. Two weeks after the chemotherapy, the therapeutic efficacy was assessed and surgery or radiotherapy was conducted. Results: Complete response ( CR ) was found in 2 cases of Group A, and partial response ( PR ) was seen in the other 12, without no response ( NR ) or progression of disease ( PD ). Adverse reactions in this group were low fever in 5 cases  and slight nausea in 8 cases. Vomiting, hair loss and overt drop of WBC counts were not found in the group. The amount of bleeding in the surgery of tongue cancer was within 20～30 mL. In group II, PR was seen in 11 of the 15 cases, and NR in 4, without CR or PD. The side effects in the group were as follows: high fever in 10 cases, nausea, vomiting and hair loss in 13 cases, with obvious drop of WBC counts in the patients. The amount of bleeding in the surgery reached at 50～95 mL. There was statistically significant differences in the curative effects and amount of bleedings during the surgery between the two groups ( P < 0.05 ). A 9 to 36-month follow-up in 25 of the patients revealed that one of the patients from Group A died of local recurrence and lymph-node metastasis at 8 months after surgery, and another one died of pulmonary metastasis at 6 months after radiotherapy. Three patients from Group B succumbed to the local recurrence. Conclusion: There are satisfactory curative effects and few adverse reactions in the patients with advanced squamous cell carcinoma of the tongue after preoperative DSA-guided ultraselective intralingual-arterial infusion of cisplatin and iodinated oil resuspended mixture, which is worthy of popularizing in clinical practice.