姚志华①, 刘艳艳①, 赵 燕①, 姚书娜①, 郭宏强①, 马 杰②, 夏庆欣②, 杨树军②. 原发性肺淋巴瘤17例回顾性分析[J]. 中国肿瘤临床, 2011, 38(12): 738-740. DOI: 10.3969/j.issn.1000-8179.2011.12.013
引用本文: 姚志华①, 刘艳艳①, 赵 燕①, 姚书娜①, 郭宏强①, 马 杰②, 夏庆欣②, 杨树军②. 原发性肺淋巴瘤17例回顾性分析[J]. 中国肿瘤临床, 2011, 38(12): 738-740. DOI: 10.3969/j.issn.1000-8179.2011.12.013
Zhihua YAO1, Yanyan LIU1, Yan ZHAO1, Shu'na YAO1, Hongqiang GUO1, Jie MA2, Qingxin XIA2, Shujun YANG1. Primary Pulmonary Lymphoma: Retrospective Analysis of17Patients[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2011, 38(12): 738-740. DOI: 10.3969/j.issn.1000-8179.2011.12.013
Citation: Zhihua YAO1, Yanyan LIU1, Yan ZHAO1, Shu'na YAO1, Hongqiang GUO1, Jie MA2, Qingxin XIA2, Shujun YANG1. Primary Pulmonary Lymphoma: Retrospective Analysis of17Patients[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2011, 38(12): 738-740. DOI: 10.3969/j.issn.1000-8179.2011.12.013

原发性肺淋巴瘤17例回顾性分析

Primary Pulmonary Lymphoma: Retrospective Analysis of17Patients

  • 摘要: 目的:探讨原发性肺淋巴瘤(PPL)的临床特点、确诊手段、病理及治疗、预后。方法:回顾性分析1999年6 月至2008年12月河南省肿瘤医院收治的17例原发性肺淋巴瘤患者的临床特点、诊断、病理类型、治疗,应用Kaplan-Meier 法行生存分析和Log-rank 检验法行差异显著性检验。统计学分析应用SPSS10.0 软件完成。结果:17例患者中7 例女性,10例男性;年龄29~73岁,中位发病年龄56岁;按照WHO2001淋巴瘤病理分类系统,全组患者均为非霍奇金淋巴瘤,其中9 例为黏膜相关淋巴组织淋巴瘤(MALTL);PPL 占同期收治恶性淋巴瘤病例数的0.81% ,占同期收治原发于结外淋巴瘤病例数的4.74% ;随访5.2~93个月,中位随访时间为62.5 个月。全组患者5 年总生存率为62.5% ,黏膜相关淋巴组织淋巴瘤(MALTL)和非黏膜相关淋巴组织淋巴瘤(non-MALTL)的5 年总生存率分别为75% 和50% ,差异具有统计学意义(P=0.047)。 结论:PPL 临床上非常少见,症状及影像学表现不特异,容易误诊,获取足够具有代表性的组织标本进行病理学检查是确诊的关键。PPL 的治疗原则尚无统一标准,由于其病理类型大多为低度恶性的MALT,因此预后较好。

     

    Abstract: Objective:To discuss the clinical and pathological characteristics, diagnosis, treatment results, and prognosis of pri -mary pulmonary lymphoma ( PPL ). Methods:The clinical characteristics, diagnostic approaches, pathologic subtypes, and treatment of 17PPL cases treated at the Tumor Hospital of He'nan between June 1999and December 2008were retrospectively analyzed. The Ka-plan-Meier method was used in the survival analysis, and the log-rank method was used in the statistical test.Results: Of the 17pa -tients, 7 were female and 10were male, with a median age of56years ( 29-73years ). According to the WHO 2001lymphoma classifi -cation system, all17cases of PPL were non-Hodgkin's lymphomas; 13patients had mucosa-associated lymphoid tissue ( MALT ) lym-phoma. PPL accounted for about 0.81% of malignant lymphomas and 4.74% of primary extranodal lymphomas during the same period at the Tumor Hospital of He'nan. The median follow-up time was 62.5 months ( 5.2-93months ). The overall survival rate of the 17pa -tients was 62.5% at 5 years; the 5-year overall survival was superior among patients with MALT lymphoma compared with those with the non-MALT lymphoma ( the 5-year overall survival rates were 75% and 50%, respectively;P = 0.047 ). Conclusion:The incidence of PPL is very low. It is easily misdiagnosed because of its nonspecific clinical and imaging manifestations. Acquiring enough represen-tative tissue specimens for pathologic examination is the key to a definitive diagnosis. At present, there is no therapeutic consensus for these patients. Most of its pathologic subtypes are MALT lymphomas; hence, PPL generally has good prognosis.

     

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