Abstract:  To explore the influencing factors of deep venous thrombosis ( DVT ) in patients with advanced epithelial ovarian cancer ( AdEOC ) after undergoing primary cytoreductive surgery. Methods: Data of 81 patients with AdEOC who underwent primary cytoreduction surgery in the First Affiliated Hospital of Fujian Medical University from January 2000 to October 2010 were retrospectively analyzed. The patients were divided into Group A with DVT and Group B without DVT. The influencing factors were analyzed by univariate and multivariate methods, including preoperative clinical parameters, i.e., age, body mass index ( BMI ), a complicated cardiovascular disease, a history of thromboembolism, preoperative serum fibrinogen, blood platelet and serum CA125; surgery-related parameters, i.e., time of surgery, optimal debulking and volume of blood loss and transfusion; and postoperative parameters, i.e., days of bed rest and use of anti-coagulation drugs. Results: In our study, the occurrence rate of postoperative DVT was 19.75%. In a comparison between Groups A and B, the univariate analysis indicated that age, BMI, a complication of cardiovascular disease, a history of previous thromboembolism, preoperative serum fibrinogen, transfusion volume, and days of bed rest were the postoperative high-risk factors of DVT ( P < 0.05 ). The multivariate logistic regression analysis showed that BMI, preoperative serum fibrinogen, and postoperative days of bed rest were the independent influencing factors for the occurrence of DVT after surgery ( P  < 0.05 ). The risk ratios were 1.790, 2.750 and 3.090, respectively. Conclusion: DVT frequently occurs in AdEOC patients with high-risk factors after cytoreductive surgery. As for prevention of postoperative DVT, more attention should be paid to patients who are obese, with high preoperative serum fibrinogen, and with tendency for longer bed-rest.