Abstract: To find new prognostic molecular markers for follicular lymphoma ( FL ) and to explore the role of lymphoma-associated macrophages (LAM) in predicting the prognosis of FL. Methods: The expression of LAM in 48 specimens of FL was detected by non-biotin HRP detection Immunohistochemistry method, and the correlations between LAM expression and patient characteristics, treatment response, and overall survival were retrospectively analyzed using the SPSS 13.0 software pack. Results: Of the 48 FL patients, 38 cases ( 79.2% ) were categorized with low-level expression, 10 cases ( 20.8% ) with high-level expression. No significant relationship between LAM expression and patient clinical characteristics was observed. The treatment response of patients with low-level expression was similar to those with high-level expression ( ORR 91.7% vs. 100.0%, P = 1.000; CR 63.2% vs. 55.6%, P = 1.000 ). Median survival time (MST) has not been reached. The MST of patients with low LAM expression was superior to that in the high expression group ( P = 0.002 ). Multivariate analysis showed LAM expression was not associated with the overall survival of patients. Conclusion: High-level LAM expression may be associated with poor FL prognosis whereas no statistical significance was observed because of the minority of patients  and insufficient follow-up. Further investigation is warranted.