Abstract:
This work summarizes the clinical features and treatment of 10 AIDS patients with malignant lymphoma seen in the Beijing Ditan Hospital. Methods: A total of 10 AIDS in-patients with malignant lymphoma in Beijing Ditan Hospital since 2009 were enrolled. Clinical manifestations, pathologic examinations, immunity levels, Epstein-Barr virus antibody examinations, complications, treatments, and outcomes were retrospectively analyzed. Results: The main clinical manifestations of these patients included intermittent fever in 2 cases, neck masses and fever in 3cases , auxiliary lymph node enlargement in 2 cases, and abdominal pain and bloating with fever in 3 cases. Up to 7 patients were pathologically diagnosed with diffuse large B cell lymphoma (DLBCL), and 3 patients were pathologically diagnosed with Burkitt's lymphoma. Up to 8 patients had CD4 cell counts below 200/µL, 2 patients had more than 200/µL. Up to 7 patients were negative for EBV-IgM antibodies and 3 patients were positive. Six patients underwent different chemotherapy treatments and their prognoses were different. One patient with Burkitt's lymphoma alternatively took CODOXM and IVAC for three turns after VP chemotherapy; ome patient with liver metastasis took R-CHOP five times, then changed therapy regimen to R-MINE, MINE. One patient with adrenal DLBCL took CHOP six times. Three patients with DLBCL took CHOP one or two times. Four patients gave up treatment. Various infections occurred, as well as side effects such as bone marrow suppression, gastrointestinal bleeding, and renal dysfunction during chemotherapy. Six patients took HAART, and four did not. Six patients died, whereas three patients got improved; and 1 patient was automatically discharged. Conclusion: AIDS patients with malignant lymphoma had various clinical manifestations, were immunocompromised, and with multiple metastasis when they were admitted; they were already in the interim or late stage of lymphoma. Chemotherapy was not effective, and additional complications occurred. HAART failed to improve patient prognosis, and the overall prognosis was poor.