刘小军, 马守成, 侯小明, 令晓玲, 张东明, 综述, 赵达, 审校. 小细胞肺癌的分子靶向治疗现状与展望[J]. 中国肿瘤临床, 2011, 38(22): 1415-1418. DOI: 10.3969/j.issn.1000-8179.2011.22.016
引用本文: 刘小军, 马守成, 侯小明, 令晓玲, 张东明, 综述, 赵达, 审校. 小细胞肺癌的分子靶向治疗现状与展望[J]. 中国肿瘤临床, 2011, 38(22): 1415-1418. DOI: 10.3969/j.issn.1000-8179.2011.22.016
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Xiaojun LIU, Shoucheng MA, Xiaoming HOU, Xiaoling LING, Dongming ZHANG, Da ZHAO, . Current Situation and Prospect of Molecular Targeted Therapies in Small-cell Lung Cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2011, 38(22): 1415-1418. DOI: 10.3969/j.issn.1000-8179.2011.22.016
Citation: Xiaojun LIU, Shoucheng MA, Xiaoming HOU, Xiaoling LING, Dongming ZHANG, Da ZHAO, . Current Situation and Prospect of Molecular Targeted Therapies in Small-cell Lung Cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2011, 38(22): 1415-1418. DOI: 10.3969/j.issn.1000-8179.2011.22.016
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小细胞肺癌的分子靶向治疗现状与展望

Current Situation and Prospect of Molecular Targeted Therapies in Small-cell Lung Cancer

    摘要
  • 摘要: 小细胞肺癌以侵袭性高、容易出现远处转移而著称，预后极差。化疗是各期小细胞肺癌治疗的基石所在。与化疗相比，分子靶向治疗具有高效、低毒的特点，是目前肿瘤治疗发展的新方向。近年来，一些分子靶向药物在治疗中小细胞肺癌患者治疗中进行了临床研究。本文将对小细胞肺癌分子靶向治疗的重要分子靶点和相应药物进行论述。

     

    Abstract: Small cell lung cancer ( SCLC ) is a highly aggressive cancer usually with distal metastasis and very poor prognosis. Chemotherapy is the treatment of choice for SCLC in all stages. Compared to conventional systemic chemotherapy, molecular targeted therapy can achieve higher therapeutic effects with lower toxic side effects. Over the past few years, clinical research on targeted anticancer medicines has been conducted in SCLC patients. In this review, potential molecular targets in SCLC tissue and corresponding targeted medicines are reviewed.

     

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