陈　明, 崔　巍, 张艳辉, 刘素香, 刘岩雪, Ximing J.Yang, 姚　欣. 透明细胞性肾细胞癌在不同组织学分类中的比较研究[J]. 中国肿瘤临床, 2011, 38(24): 1555-1558. DOI: 10.3969/j.issn.1000-8179.2011.24.020
引用本文: 陈　明, 崔　巍, 张艳辉, 刘素香, 刘岩雪, Ximing J.Yang, 姚　欣. 透明细胞性肾细胞癌在不同组织学分类中的比较研究[J]. 中国肿瘤临床, 2011, 38(24): 1555-1558. DOI: 10.3969/j.issn.1000-8179.2011.24.020
shu
Ming CHEN, Wei CUI, Yanhui ZHANG, Suxiang LIU, Yanxue LIU, Ximing J. YANG, Xin YAO. Clear Cell Renal Cell Carcinoma: Comparative Research in Different Histological Classifications[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2011, 38(24): 1555-1558. DOI: 10.3969/j.issn.1000-8179.2011.24.020
Citation: Ming CHEN, Wei CUI, Yanhui ZHANG, Suxiang LIU, Yanxue LIU, Ximing J. YANG, Xin YAO. Clear Cell Renal Cell Carcinoma: Comparative Research in Different Histological Classifications[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2011, 38(24): 1555-1558. DOI: 10.3969/j.issn.1000-8179.2011.24.020
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透明细胞性肾细胞癌在不同组织学分类中的比较研究

Clear Cell Renal Cell Carcinoma: Comparative Research in Different Histological Classifications

    摘要
  • 摘要: 比较2004年WHO肾细胞癌组织学分类标准与1997年WHO及更早的分类标准的异同，总结常见的诊断差异及可能原因，纠正及更新对肾细胞癌的传统病理分类的观念。方法：收集天津医科大学肿瘤医院2004年2月至2008年2月间，根治性肾切除术后病理诊断为透明性肾细胞癌249例，按2004年WHO肾癌组织学分类标准重新分类，并收集相关临床资料进行分析。结果：原分类法的249例透明细胞癌，经重新分类后，发现透明细胞癌176例，乳头状肾细胞癌42例，嫌色细胞癌5例，多房性囊性肾细胞癌3例，混合型肾细胞癌23例（透明细胞癌+乳头状肾细胞癌21例，乳头状肾细胞癌+嫌色性肾细胞癌2例）。结论：部分乳头状肾细胞癌与嫌色肾细胞癌过去易被诊断为透明细胞癌，两者具有相似的胞浆特点，及对其组织学特点认识不清是其主要原因；中国人乳头状肾细胞癌的发病率与国外相近，且其亚型的分类及诊断有待进一步的研究。

     

    Abstract: To compare the old classification and 2004 World Health Organization (WHO)  histological classification in renal cell carcinoma, summarize the differences and possible reasons, and correct the traditional pathological concepts about kidney cancer. Methods: A total 249 cases, in which pathological results showed clear cell renal cell carcinomas after radical nephrectomy during 2004 and 2008 in Tianjin Medical University Cancer Institute and Hospital, were reclassified according to the 2004 WHO renal cell carcinoma histological classification system. Results: After reclassification, 179 cases of clear cell renal cell carcinoma ( CCRCC ), 42 cases of papillary renal cell carcinoma ( PRCC ), 5 cases of chromophobe renal cell carcinoma (ChRCC), 3 cases of multilocular cystic renal cell carcinoma, and 23 cases of mixed cell renal cell carcinoma ( CCRCC + PRCC 21 cases, PRCC + ChRCC 2 cases ), were classified. Conclusion: Some ChRCCs and PRCCs were easily diagnosed as CCRCC in the past. The similar cytoplasm and some confusion with PRCC and ChRCC are the main reasons. Thus, the diagnostic standard of PRCC subtypes needs further study.

     

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