Abstract: To investigate the feasibility and long term outcome of simultaneous liver and colorectal resection for central synchronous colorectal liver metastasis. Methods: A totoal 23 colorectal liver metastasis patients, who underwent simultaneous colorectomy and hepatectomy between January 1995 and December 2010 in the Cancer Hospital, Chinese Academy of Medical Science, were retrospectively analyzed. Results: The group included 16 males and 7 females, with age ranging from 34 years to 68 years. No deaths occurred within the 30 days after surgery. The overall median operative duration was 306 ± 72 minutes, intraoperative bleeding was 421 ± 126 mL, and the median hospital stay was 11.4 ± 1.8 days. Six cases received blood transfusion, 4 had pleural effusion, 1 had bile leakage, and 1 had thrombus of the lower limb. The 1-, 3-, and 5-year survival rates were 74.0%, 48.5%, and 17.0%, respectively. All liver functions recovered to Child A within 1 week. Conclusion: Simultaneous liver and colorectal resections are safe and effective for synchronous central colorectal liver metastasis.