施明亮, 陈　勇, 综述, 刘　巍, 审校. miR-21与消化系统肿瘤[J]. 中国肿瘤临床, 2011, 38(24): 1604-1607. DOI: 10.3969/j.issn.1000-8179.2011.24.033
引用本文: 施明亮, 陈　勇, 综述, 刘　巍, 审校. miR-21与消化系统肿瘤[J]. 中国肿瘤临床, 2011, 38(24): 1604-1607. DOI: 10.3969/j.issn.1000-8179.2011.24.033
shu
Mingliang SHI, Yong CHEN, Wei LIU, . miR-21 and Digestive System Cancers[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2011, 38(24): 1604-1607. DOI: 10.3969/j.issn.1000-8179.2011.24.033
Citation: Mingliang SHI, Yong CHEN, Wei LIU, . miR-21 and Digestive System Cancers[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2011, 38(24): 1604-1607. DOI: 10.3969/j.issn.1000-8179.2011.24.033
shu

miR-21与消化系统肿瘤

miR-21 and Digestive System Cancers

    摘要
  • 摘要: microRNA（miRNA）是一类内源性非编码蛋白短链RNA，参与细胞增殖、分化、凋亡等多种重要活动的调控。近来研究发现miRNA具有癌基因或抑癌基因样作用，参与多种恶性肿瘤的演进，是肿瘤发生、发展过程中的重要分子，其中miR-21最受关注。miR-21在消化系统肿瘤如食管癌、胃癌、肝癌、胆管癌、胰腺癌、结直肠癌等的细胞或组织中表达上调，发挥着类似于癌基因的作用。miR-21通过对靶基因的调控，增强了肿瘤细胞的增殖、浸润及转移能力，并与消化系统肿瘤患者的无复发时间与总生存时间密切相关。目前体外研究证实，miR-21抑制物能够提高恶性肿瘤细胞对化疗药物的敏感性，使化疗药物的杀伤肿瘤效果更加明显，而miR-21类似物，可抵消一部分化疗药物的疗效，从而提示抑制miR-21的表达或阻碍miR-21与靶基因的相互作用在消化系统肿瘤的治疗中具有广阔的应用前景。本文就miR-21在消化系统肿瘤的调控机制、增殖与凋亡、侵袭、耐药与转移中的作用，及其临床价值作一综述。

     

    Abstract: miRNA is a kind of endogenous non-coding short RNA, which regulates many tumor biological behaviors, such as cell multiplication, differentiation, and apoptosis. Studies recently discovered that miRNA takes on the function of oncogene or anti-oncogene and participates on the evolution of many kinds of malignant tumors. Thus, miRNA is significant in the development process of tumors. In addition, miR-21 is valued highly in miRNA. The mechanism of cell proliferation and apoptosis, invasion, and metastasis, as well as the clinical value of digestive system cancers will be reviewed in this paper.

     

    • HTML全文
    • 参考文献(0)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回