MicroRNA与肿瘤免疫关系的研究进展

刘磊; 刘臣海; 黄强

doi:10.3969/j.issn.1000-8179.2012.01.014

MicroRNA与肿瘤免疫关系的研究进展

doi: 10.3969/j.issn.1000-8179.2012.01.014

刘磊^①,
刘臣海^②,
黄强^③, ,

①.
安徽医科大学附属安徽省立医院胆胰外科在读研究生
②.
胆胰外科
③.
普外科（合肥市230001）

详细信息

通讯作者:
黄强 hq-sohu@sohu.com

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- 文章访问数: 12
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- 被引次数: 0
出版历程
- 收稿日期: 2011-04-05
- 修回日期: 2011-07-12

MicroRNA and Tumor Immunity

Lei LIU^①,
Chenhai LIU^②,
Qiang HUANG^{③
, ,}

①.
Anhui Provincial Hospital Affiliated to Anhui Medical University
②.
Department of Biliary
③.
Pancreatic Surgery, Hefei 230001, China

More Information

Corresponding author: Qiang HUANG; E-mail:hq-sohu@sohu.com

摘要

摘要: MicroRNA又称miRNA，是真核生物细胞中一类非编码小分子RNA，主要在转录后水平发挥调控靶基因的作用。MicroRNA参与调节细胞生长、发育、分化、增殖和凋亡等生命过程，影响着几乎所有的信号通路，参与各种生理病理过程，特别在肿瘤的发生和发展中发挥着重要的调节作用。研究MicroRNA与肿瘤的关系是近年来备受各界关注的热点之一。特别是对机体抗肿瘤的免疫学方面的影响，而这些方面的重大突破将为肿瘤的诊断和治疗提供新的思路。本文就MicroRNA的生物学功能及其对机体抗肿瘤免疫机制的影响进行综述。
- MicroRNA /
- 肿瘤 /
- 免疫
Abstract: MicroRNA, also known as miRNA, is a class of noncoding small-molecule RNAs in eukaryotic cells which plays a major role in the post-transcriptional level of target-gene regulation. MicroRNA is involved in the regulation of life processes, such as cell growth, development, differentiation, proliferation, and apoptosis, and affects almost all of the signaling pathways involved in various physiological and pathological processes. It also plays an important regulatory role in the development and progression of tumors. The relationship between microRNA and cancer research has recently gained much attention. The impact of microRNA on the body, particularly its immunological anti-tumor mechanisms, and the major breakthrough in the diagnosis and treatment of cancer provide new ideas. In the current paper, the biological function and anti-tumor immune mechanisms of microRNA were reviewed.
- MicroRNA /
- Tumor /
- Immunity

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参考文献(23)

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