-
摘要: MicroRNA又称miRNA,是真核生物细胞中一类非编码小分子RNA,主要在转录后水平发挥调控靶基因的作用。MicroRNA参与调节细胞生长、发育、分化、增殖和凋亡等生命过程,影响着几乎所有的信号通路,参与各种生理病理过程,特别在肿瘤的发生和发展中发挥着重要的调节作用。研究MicroRNA与肿瘤的关系是近年来备受各界关注的热点之一。特别是对机体抗肿瘤的免疫学方面的影响,而这些方面的重大突破将为肿瘤的诊断和治疗提供新的思路。本文就MicroRNA的生物学功能及其对机体抗肿瘤免疫机制的影响进行综述。Abstract: MicroRNA, also known as miRNA, is a class of noncoding small-molecule RNAs in eukaryotic cells which plays a major role in the post-transcriptional level of target-gene regulation. MicroRNA is involved in the regulation of life processes, such as cell growth, development, differentiation, proliferation, and apoptosis, and affects almost all of the signaling pathways involved in various physiological and pathological processes. It also plays an important regulatory role in the development and progression of tumors. The relationship between microRNA and cancer research has recently gained much attention. The impact of microRNA on the body, particularly its immunological anti-tumor mechanisms, and the major breakthrough in the diagnosis and treatment of cancer provide new ideas. In the current paper, the biological function and anti-tumor immune mechanisms of microRNA were reviewed.
-
[1] ShabMina SA, Spifidonov NA. The mammalian transcriptome and the function of noncoding DNA sequences[J]. Genome Biol, 2004, 5(4): 105. doi: 10.1186/gb-2004-5-4-105 [2] Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 [J]. Cell, 1993, 75(5): 843-854. doi: 10.1016/0092-8674(93)90529-Y [3] Pasquinelli AE, Reinhart BJ, Slack F, et al. Conservation of the sequence and temtral expression of let-7 heterechronic regulatory[J]. Nature, 2000, 408(6808): 86—89. doi: 10.1038/35040556 [4] Hwang HW, Mendell JT. MicroRNAs in cell proliferation, cell death, and tumorigenesis[J]. Br J Cancer, 2006, 94(6): 776-780. doi: 10.1038/sj.bjc.6603023 [5] Baek D, Villen J, Shin C, et al. The impact of microRNAs on protein output[J]. Nature, 2008, 455(7209): 64-71. doi: 10.1038/nature07242 [6] Selbach M, Schwanhausse B, Thierfelder N, et al. Widespread changes in protein synthesis induced by microRNAs[J]. Nature, 2008, 455 (7209): 58-63. doi: 10.1038/nature07228 [7] 龚非力. 医学免疫学[M]. 北京: 科学出版社, 2009: 287-288. [8] 侯召华, 张建, 田志刚. MicroRNA调控固有免疫应答的分子机制[J]. 生物化学与生物物理进展, 2008, 35(10): 1131-1136 doi: 10.3321/j.issn:1000-3282.2008.10.005 [9] Bezman NA, Cedars E, Steiner DF, et al. Distinct requirements of microRNAs in NK cell activation, survival, and function[J]. J Immunol, 2010, 185(7): 3835-3846. doi: 10.4049/jimmunol.1000980 [10] Zhu XM, Han T, Wang XH, et al. Overexpression of miR-152 leads to reduced expression of human leukocyte antigen-G and increased natural killer cell mediated cytolysis in JEG-3 cells[J]. Am J Obstet Gynecol, 2010, 202(6): 592. e1-e7. http://www.sciencedirect.com/science/article/pii/s0002937810002899 [11] Xu H, Cheung IY, Guo HF, et al. MicroRNA miR-29 modulates expression of immunoinhibitory molecule B7-H3: potential implications for immune based therapy of human solid tumors[J]. Cancer Res, 2009, 69(15): 6275-6281. doi: 10.1158/0008-5472.CAN-08-4517 [12] Luers AJ, Loudig OD, Berman JW. MicroRNAs are expressed and processed by human primary macrophages[J]. Cell Immunol, 2010, 263(1): 1-8. doi: 10.1016/j.cellimm.2010.03.011 [13] Tili E, Croce CM, Michaille JJ. miR-155: on the crosstalk between inflammation and cancer[J]. Int Rev Immunol, 2009, 28(5): 264-284. doi: 10.1080/08830180903093796 [14] Berland R, Wortish HH. Origins and functions of B-1 cells with notes on the role of CD5[J]. Annu Rev Immunol, 2002, 20: 253-300. doi: 10.1146/annurev.immunol.20.100301.064833 [15] Liston A, Linterman M, Lu LF. MicroRNA in the adaptive immune system, in sickness and in health[J]. J Clin Immunol, 2010, 30(3): 339-346. doi: 10.1007/s10875-010-9378-5 [16] Auer RL. The coming of age of microRNA for B cell lymphomas[J]. Histopathology, 2011, 58(1): 39-48. doi: 10.1111/j.1365-2559.2010.03698.x [17] Zhou B, Wang S, Mayr C, et al. miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely[J]. Proc Natl Acad Sci U S A, 2007, 104(17): 7080-7085. doi: 10.1073/pnas.0702409104 [18] Lykken EA, Li QJ. microRNAs at the regulatory frontier: an investigation into how microRNAs impact the development and effector functions of CD4 T cells[J]. Immunol Res, 2011, 49(1-3): 87-96. doi: 10.1007/s12026-010-8196-4 [19] Taganov KD, Boldin MP, Chang KJ, et al. NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses[J]. Proc Natl Acad Sci U S A, 2006, 103(33): 12481-12486. doi: 10.1073/pnas.0605298103 [20] Xue Q, Guo ZY, Li W, et al. Human activated CD4(+) T lymphocytes increase IL-2 expression by downregulating microRNA-181c [J]. Mol Immunol, 2011, 48(4): 592-599. doi: 10.1016/j.molimm.2010.10.021 [21] Kanemaru H, Fukushima S, Yamashita J, et al. The circulating microRNA-221 level in patients with malignant melanoma as a new tumor marker[J]. J Dermatol Sci, 2011, 61(3): 187-193. doi: 10.1016/j.jdermsci.2010.12.010 [22] Shen J, Todd NW, Zhang H, et al. Plasma microRNAs as potential biomarkers for non-small-cell lung cancer[J]. Lab Invest, 2011, 91 (4): 579-587. doi: 10.1038/labinvest.2010.194 [23] Bi Y, Liu G, Yang R. MicroRNAs: novel regulators during the immune response[J]. J Cell Physiol, 2009, 218(3): 467-472. doi: 10.1002/jcp.21639
点击查看大图
计量
- 文章访问数: 12
- HTML全文浏览量: 16
- PDF下载量: 1
- 被引次数: 0