余辉, 黄秀英, 胡袆, 区伟, 朱志华, 王军业, 杨寒, 鹿彬, 张兰军, 王欣. 检测外周血Lunx mRNA表达在诊断非小细胞肺癌微转移中的临床价值[J]. 中国肿瘤临床, 2012, 39(2): 74-76, 84. DOI: 10.3969/j.issn.1000-8179.2012.02.004
引用本文: 余辉, 黄秀英, 胡袆, 区伟, 朱志华, 王军业, 杨寒, 鹿彬, 张兰军, 王欣. 检测外周血Lunx mRNA表达在诊断非小细胞肺癌微转移中的临床价值[J]. 中国肿瘤临床, 2012, 39(2): 74-76, 84. DOI: 10.3969/j.issn.1000-8179.2012.02.004
shu
Hui YU, Xiuying HUANG, Hui HU, Wei QU, Zhihua ZHU, Junye WANG, Han YANG, Bin LU, Lanjun ZHANG, Xin WANG. Clinical Significance of Lunx mRNA Detection in the Peripheral Blood of Non-Small Cell Lung Cancer Patients[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2012, 39(2): 74-76, 84. DOI: 10.3969/j.issn.1000-8179.2012.02.004
Citation: Hui YU, Xiuying HUANG, Hui HU, Wei QU, Zhihua ZHU, Junye WANG, Han YANG, Bin LU, Lanjun ZHANG, Xin WANG. Clinical Significance of Lunx mRNA Detection in the Peripheral Blood of Non-Small Cell Lung Cancer Patients[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2012, 39(2): 74-76, 84. DOI: 10.3969/j.issn.1000-8179.2012.02.004
shu

检测外周血Lunx mRNA表达在诊断非小细胞肺癌微转移中的临床价值

Clinical Significance of Lunx mRNA Detection in the Peripheral Blood of Non-Small Cell Lung Cancer Patients

    摘要
  • 摘要:
      目的  探讨检测非小细胞肺癌(NSCLC)患者外周血Lunx mRNA表达对于诊断肿瘤微转移的临床价值。
      方法  采用荧光定量RT-PCR技术分别对98例NSCLC患者和20例正常对照组外周血Lunx mRNA的表达进行检测分析。
      结果  NSCLC组患者外周血Lunx mRNA的阳性率为74.5%, 显著高于对照组的15%(χ2=25.642, P < 0.05);Ⅲ期NSCLC患者的阳性率显著高于Ⅰ期和Ⅱ期患者的阳性率(χ2=21.014, P < 0.05);淋巴结转移阳性和阴性患者的外周血中CK19mRNA阳性率分别为93.2%和46.2%, 差异有统计学意义(χ2=27.372, P < 0.05);不同细胞分化程度与NSCLC患者外周血微转移阳性率有密切关系(χ2=30.004, P < 0.05);NSCLC患者外周血微转移与年龄、性别、吸烟史、原发肿瘤部位无密切关系(P>0.05)。
      结论  Lunx mRNA的高表达可能与非小细胞肺癌的微转移有关, 可作为检测NSCLC患者微转移的分子标志物, 其有助于早期诊断肺癌转移, 指导临床分期和治疗。

     

    Abstract:
      Objective  To evaluate the clinical significance of Lunx mRNA detection in the peripheral blood of patients with non-small cell lung cancer (NSCLC).
      Methods  Lunx mRNA expression was detected by fluorescence quantitative reverse transcription polymerase chain reaction in the peripheral blood from 98 NSCLC patients and a control group of 20 healthy adults.
      Results  The positive rate of Lunx mRNA in peripheral blood in the NSCLC group was 74.5%, significantly higher than that in the control group (χ2 = 25.642, P < 0.05). The expression rate increased significantly as the clinical stage progressed (χ2 = 21.014, P < 0.05). Significant difference was found among the different lymph node metastasis status ( χ2 = 27.372, P < 0.05) and different cell differentiation status (χ2 = 30.004, P < 0.05). No significant difference was noted between the positive rates of Lunx mRNA for different ages, gender, history of smoking, and primary tumor position of NSCLC (P > 0.05).
      Conclusion  Higher Lunx mRNA expression in the peripheral blood of NSCLC patients may be related to the micro-metastasis of the disease and might be a valuable marker for micrometastasis. Lunx mRNA detection is significant for the early prediction of NSCLC prognosis and metastasis.

     

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