Abstract:
Objective To explore the value of serum Creatinine(Cr), Cystain c(Cys C), Urea, β2 microglobulin(β2-MG), Serum Creatinine, and the CystatinC-based estimated glomerular filtration rate(eGFR) in diagnosing renal dysfunction in malignant rumor patients.
Methods The levels of Serum Cr, Cys C, Urea, β2-MG, and Cr from the 24 h urine and serum of 145 malignant tumor patients were assayed.CCr was calculated using the Cockcroft-Gault equation, and the calculated GFR was called cGFR.Cr of the tumor patients was determined by a modified and simplified equation of the modifcation of diet in renal disease to calculate eGFR, and the result was called mGFR.The eGFR equation calculated based on the joint outcome of serum CysC and Cr levels was called uGFR.
Results Significant increases in CysC and P2-MG were observed in each stage of renal function impairment in these patients compared with the normal controls(P < 0.05).Serum Urea obviously increased at beginning of StageⅡ(P < 0.05), and serum Cr was insignificantly increased until StageⅢ(P < 0.05).The rate of abnormity of CysC remained higher in StageⅠtoⅢpatients with renal function impairments compared with serum Cr in the same patients.A good correlation existed between the evaluations for both mGFR and uGFR and cGFR, although a deviation was observed.The concordance was higher between uGFR and cGFR than between uGFR and mGFR. and the accuracy between uGFR and cGFR was better than between uGFR and mGFR.
Conclusion The detection of serum CysC and P2-MG is favorable for the early diagnosis of the renal function impairments in malignant tumor patients.A satisfactory applicable value was found in the clinical diagnosis of uGFR for renal impairment based on the outcome of joint serum CysC and Cr levels.
下载: