即刻早期基因IEX-1与肿瘤

耿莉娜; 张晓雪; 韩丽萍

doi:10.3969/j.issn.1000-8179.2012.04.014

即刻早期基因IEX-1与肿瘤

doi: 10.3969/j.issn.1000-8179.2012.04.014

郑州大学第一附属医院妇产科（郑州市450052）

详细信息

通讯作者:
韩丽萍 HanLp0826@sohu.com.cn

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- 被引次数: 0
出版历程
- 收稿日期: 2011-10-25
- 修回日期: 2011-11-20

Research on Immediate Early Response Gene X-1 and Tumor

Department of Gynecology and Obstetrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

More Information

Corresponding author: Liping HAN, E-mail: HanLp0826@sohu.com.cn

摘要

摘要: 即刻早期反应基因IEX-1(immediate early response gene X-1)作为即刻早期基因家族之一, 参与细胞的多种生物学效应, 其转录和表达受多种因素的调控如NF-κB、P53、SP1、AP2、1a-25(OH)2D3、TNF-α及电离辐射等。研究发现, IEX-1在多种肿瘤细胞中转录及表达降低或缺失, 而电离辐射等则可以激活诱导其在多种类型肿瘤细胞和正常细胞中快速的表达, 其激活表达与辐射后细胞的生长、周期、凋亡等的改变密切相关。辐射可诱导特性使其具有潜在的临床和基因工程生产应用前景。
- IEX-1 /
- 肿瘤 /
- 凋亡 /
- 辐射 /
- 敏感性
Abstract: As a member of the immediate early gene family, immediate early response gene X-1(IEX-1) participates in multiple biological effects of the cells.Several factors, such as NF-κB, 1a-25(OH) 2D3, UVB, AP2, SPl, P53, and TNF-a can modulate IEX-1 expression and transcription.Studies have shown that IEX-1 expression and transcription are down-regulated or absent in many tumor cells.The IEX-1 gene can be activated at an early stage in many types of tumor and normal cells by ionizing radiation.IEX-1 activation and consequent expression are closely related to the change of irradiated cell growth, cell cycle, and apoptosis.The radiation-induced characteristics of IEX-1 gene bestows it potential for clinical and genetic engineering production.
- Immediate early response gene X-1 /
- Tumor /
- Apoptosis /
- Radiation /
- Sensitivity

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参考文献(29)

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