Abstract:
Objective To investigate the expression of P16, P53, and CyclinD1 protein in low-grade and high-grade ovarian serous carcinoma and its clinical significance. The clinical data and pathological findings were analyzed.
Methods Fourty five cases of ovarian serous carcinoma (19 cases of low-grade and 26 cases of high-grade carcinoma) and 25 cases of borderline ovarian serous tumors were selected. Immunohistochemical study of P16, P53, and CyclinD1 was performed in all 70 cases.
Results The high-grade serous carcinoma had a significantly higher expression level of P53 (69% versus 5%), while low-grade carcinoma had a significantly higher expression level of CyclinD1 (89% versus 15%). Significant differences were observed in the expression between P53 and CyclinD1. An inverse correlation existed between the expression of P53 and CyclinD1 in tumor grade, r = 0.211. No difference was observed in the expression of P16 between low-grade and high-grade ovarian serous carcinoma (84% versus 92%).
Conclusion P53 over-expression was more frequently detected in high-grade than on low-grade ovarian serous carcinoma. CyclinD1 over-expression was more frequently detected in low-grade ovarian serous carcinomas. Conventional high-grade serous adenocarcinoma is distinct from low-grade serous adenocarcinoma. P 16 over-expression was detected more frequently in ovarian serous carcinoma.