CD105和VEGF在水泡状胎块中的表达及意义

刘艳; 高健; 师宜荃; 赵立武; 刘易欣

doi:10.3969/j.issn.1000-8179.2012.09.021

CD105和VEGF在水泡状胎块中的表达及意义

doi: 10.3969/j.issn.1000-8179.2012.09.021

刘艳^①,
高健^②,
师宜荃^②,
赵立武^{②, ③},
刘易欣^②, ,

①.
天津医科大学－中心临床学院妇产科（天津市300192）
②.
天津医科大学中心妇产临床学院病理科
③.
天津市宁河县医院妇产科

基金项目:

天津市自然科学基金 06YFJMJC08000

详细信息

通讯作者:
刘易欣 yixinliu66@yahoo.com.cn

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出版历程
- 收稿日期: 2012-01-31
- 修回日期: 2012-04-13

Expression and Significance of CD105 and VEGF in Hydatidiform Mole

Yan LIU^①,
Jian GAO^②,
Yiquan SHI^②,
Liwu ZHAO^{②, ③},
Yixin LIU^{②
, ,}

①.
Department of Gynecology and Obstetrics, First Central Clinic Institute of Tianjin Medical University, Tianjin 300192, China
②.
Department of Pathology, Central Gynecology and Obstetrics Clinic Institute of Tianjin Medical University, Tianjin 300100, China
③.
Department of Gynecology and Obstetrics, Ninghe Country Hospital, Tianjin 301500, China

Funds:

the Natural Science Foundation of Tianjin 06YFJMJC08000

More Information

Corresponding author: Yixin LIU, E-mail: yixinliu66@yahoo.com.cn

摘要

摘要: 目的研究CD105及VEGF在水泡状胎块（hydatidiform mole，HM）与水肿性流产（hydropic abortus，HA）绒毛滋养细胞中的表达差异及意义。方法采用免疫组织化学S-P法分别检测20例正常妊娠（normal pregnancy，NP），30例HA，20例部分性水泡状胎块（partial hydatidiform mole，PHM）和20例完全性水泡状胎块（complete hydatidiform mole，CHM）的绒毛滋养细胞中CD105和VEGF的表达水平。结果 1）CD105在HM中阳性表达率明显高于HA和NP，差异有统计学意义（P < 0.05）；2）VEGF在HM中阳性表达率低于HA和NP，差异有统计学意义（P < 0.05）；3）经Spearman等级相关检验，CD105和VEGF在HA与HM中表达呈负相关（r=-0.447，P < 0.05）。结论在HM绒毛滋养细胞中，VEGF的表达下降与CD105的表达增强可能在滋养细胞增殖与侵袭作用中起着一定作用。CD105和VEGF可作为标记绒毛滋养细胞的免疫组织化学标记物，用于HM和HA的鉴别诊断。
- 水泡状胎块 /
- 水肿性流产 /
- CD105 /
- 血管内皮生长因子
Abstract: Objective To research the different expression and significance of CD105 and vascular endothelial growth factor (VEGF) in villous trophoblast between hydatidiform mole (HM) and hydropic abortus (HA). Methods Immunohistochemical SP method was used to detect the expression level of CD105 and VEGF in villous trophoblast with 20 cases of normal pregnancy (NP), 30 cases of HA, 20 cases of partial hydatidiform mole (PHM) and 20 cases of complete hydatidiform mole (CHM). Results The expression rates of CD105 in HM were significantly higher than those in HA and NP, the differences were statistically significant (P < 0.05). The expression rates of VEGF in HM were lower than those in HA and NP, the differences were statistically significant (P < 0.05). The result of Spearman correlation test showed a negative correlation between CD105 and VEGF expression in HM and HA (r = - 0.447, P < 0.05). Conclusion The decreased expression of VEGF and the increased expression of CD105 may be associated with the proliferation and invasion of the villous trophoblast in HM. CD105 and VEGF can be used as immunohistochemcial markers of villous trophoblasts for differential diagnosis of HM and HA.
- Hydatidiform mole /
- Hydropic abortus /
- CD105 /
- Vascular endothelial growth factor

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图 1 CD105在不同组织绒毛滋养细胞的表达（S-P×100）

A：CD105在NP组弱表达；B：CD105在HA组弱表达；C：CD105在PHM组强表达；D：CD105在CHM组强表达

Figure 1. Expression of CD105 in villous trophoblasts of different tissues

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图 2 CD105在NP血管内皮细胞的表达（S-P×200）

A：CD105在蜕膜血管内皮细胞阳性表达；B：CD105在绒毛间质血管内皮细胞失表达

Figure 2. Expression of CD105 in vascular endothelial cells of NP

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图 3 VEGF在不同组织绒毛滋养细胞的表达（S-P×100）

A：VEGF在NP组强表达；B：VEGF在HA组强表达；C：VEGF在PHM组弱表达；D：VEGF在CHM组弱表达

Figure 3. Expression of VEGF in villous trophoblasts of different tissues

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表 1 CD105和VEGF在NP、HA、PHM及CHM绒毛滋养细胞中的表达

Table 1. Expression of CD105 and VEGF in villous trophoblasts of NP, HA, PHM, and CHM

参考文献(12)

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