Diagnostic Values of Carbohydrate Antigen 125 in Multiple Tumor Marker Protein Chip Detection Systems for Malignant Tumors
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摘要:
目的 探讨多肿瘤标志物蛋白芯片中糖链抗原CA125对恶性肿瘤的诊断价值。 方法 收集第三军医大学大坪医院可供分析的25 076例多肿瘤蛋白芯片检测结果，分析CA125在不同人群、不同肿瘤中升高情况，以及CA125升高伴随其他检测指标升高在肿瘤中的分布情况。 结果 CA125在恶性肿瘤患者中明显高于良性病变患者及正常体检者，而且卵巢癌最高（51.92%），其次为胰腺癌（49.25%）和肝癌（42.56%）；同时升高的指标以CEA最为常见，其次为CA199、CA242和Ferritin，CA125/CEA同时升高最常见于结直肠癌（83.87%），其次为乳腺癌（59.72%），CA125/CA199同时升高最常见于结直肠癌（90.97%）和胰腺癌（78.63%），CA125/CA242伴随升高最常见于结直肠癌（92.26%）和胰腺癌（74.81%），CA125+CEA+CA199及CA125+CEA+CA199+CA242升高均最常见于肺癌。 结论 CA125单项指标升高对卵巢癌、胰腺癌及肝癌的诊断有较高的价值，CA125伴随或联合CEA、CA199、CA242检测有利于提高结直肠癌、胰腺癌、肺癌的诊断阳性率。 Abstract:Objective To investigate the expression of carbohydrate antigen 125 (CA125), its association with other markers, and their clinical significance in a variety of populations using protein chip detective systems. Methods A total of 25, 076 cases detected with multiple tumor marker chips from 2004 to 2011 were collected. The expression levels of CA125 and its association with other markers were analyzed in various populations and patients with different types of tumor. Results CA125 expression was significantly elevated in patients with malignant tumors compared with patients with benign disease and healthy individuals. The CA125 positive rate appeared to be the highest in ovarian cancer (59.72%), followed by that in pancreatic (49.25%) and liver (42.56%) cancers. The most common accompanying marker was CEA; other less common markers were CA199, CA242, and ferritin. The CA125/CEA combination occurred most frequently in colorectal cancer (83.87%) followed by breast cancer (59.72%). CA125/CA199 was most prevalent in colorectal (90.97%) and pancreatic (78.63%) cancers. CA125/CA242 frequently appeared in colorectal (92.26%) and pancreatic (74.81%) cancers. CA125+CEA+CA199 and CA125+CEA+CA199+CA242 increase were most common in lung cancer. Conclusion Elevated CA125 is a good indicator of ovarian, pancreatic, and liver cancers. The detection of CA125 combined with CEA, CA199, and CA242 has significance in improving the diagnosis of colorectal, pancreatic, and lung cancers. -
Key words:
- Tumor marker /
- Multiple tumor marker protein chip /
- CA125
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表 1 CA125升高在各种肿瘤中的分布
例（%） Table 1. Increased level of CA125 in different cancer types
表 2 CA125伴随其他指标升高在各组中的分布情况
例（%） Table 2. Increased level of CA125 and accompanied markers in different tumor types
表 3 CA125升高患者中常见伴随升高指标在各种肿瘤中的分布情况
例（%） Table 3. Increased level of commonly accompanied markers in different tumors types with increased level of CA125
表 4 CA125与常见联合指标升高情况
Table 4. Combinations of increased level of CA125 and other markers
表 5 CA125常见联合其他指标升高情况在各种肿瘤中的分布
例（%） Table 5. Increased level of CA125 and other markers in different tumor types
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[1] 朱自力, 刘继斌, 崔学军. 乳腺癌血清CEA, CA125和CA15-3水平与骨转移之间的关系分析[J]. 现代检验医学杂志, 2010, 25(6): 105-107. https://www.cnki.com.cn/Article/CJFDTOTAL-QYWA201102138.htm [2] 杨雪琴, 仲召阳, 王东, 等. C12多肿瘤标志物蛋白芯片监测胃肠道肿瘤复发转移的临床评价[J]. 重庆医学, 2010, 39(4): 427-429. doi: 10.3969/j.issn.1671-8348.2010.04.018 [3] 仲召阳, 王东, 李增鹏, 等. 多肿瘤标志物蛋白质芯片检测对肿瘤诊断的临床意义[J]. 第三军医大学学报. 2008, 30(17): 1658-1660. doi: 10.3321/j.issn:1000-5404.2008.17.021 [4] 崔永琴. 检测血清CA125对恶性肿瘤的诊断价值[J]. 中国现代药物应用, 2010, 4(4): 96-97. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWYY201004089.htm [5] 王华玲, 李清苗. 联合检测CA125和CA19-9在卵巢癌诊断中的意义[J]. 中国社区医师·医学专业, 2011, 13(11). https://www.cnki.com.cn/Article/CJFDTOTAL-ZGSQ201111196.htm [6] Aggarwal P, Kehoe S. Serum tumour markers in gynaecological cancers[J]. Maturitas, 2010, 67(1): 46-53. [7] 陈志刚, 李庆洁. OPN、CEA、CA125、CA19-9联合检测对胰腺癌诊断的临床意义[J]. 河南职工医学院学报, 2011, 23(2): 181-182. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZG201102026.htm [8] 左新华, 周斌. CA153、CA125、CEA联合检测在乳腺癌诊断中的应用价值[J]. 中国医药科学, 2011, 1(10): 135-01. https://www.cnki.com.cn/Article/CJFDTOTAL-GYKX201110081.htm [9] 王碧玉, 张友谊. 结直肠恶性肿瘤手术前后血清CEA、CA199和CA125的变化及临床意义[J]. 右江民族医学院学报. 2011, 34(3): 281-282. https://www.cnki.com.cn/Article/CJFDTOTAL-YJMZ201103014.htm [10] Treanor D, Quirke P. Pathology of Colorectal Cancer[J]. Clinical Oncology, 2007, 19(10): 769-776. [11] 罗远芳, 黄俊. 联合检测血清CEA、CA125、CA153在N0期肺腺癌中的临床意义[J]. 临床医学工程, 2011, 18(3): 326-328. https://www.cnki.com.cn/Article/CJFDTOTAL-YBQJ201103005.htm [12] 郑辉, 吴赟, 孔建新, 等. 多肿瘤标志物蛋白芯片检测系统的临床应用分析[J]. 安徽医药, 2006, 10(4): 273-275. https://www.cnki.com.cn/Article/CJFDTOTAL-AHYY200604019.htm [13] 张亚南, 冀杨, 贾楠, 等. 多肿瘤标志物蛋白芯片检测系统在消化系统疾病的应用评价[J]. 中国实验诊断学, 201, 1(3): 500-503. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSZD201103038.htm -
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