S-100和NCAM在腺样囊性癌组织中的表达及意义

杜咏梅; 郭煜; 骆树瑜; 李蕊

doi:10.3969/j.issn.1000-8179.2012.10.012

S-100和NCAM在腺样囊性癌组织中的表达及意义

Expression and Significance of S-100 and NCAM in Adenoid Cystic Carcinoma

摘要

摘要:
目的分析腺样囊性癌(adenoid cystic carcinoma, ACC)的临床病理特点, 观察雪旺细胞标记物S-100和神经细胞粘附分子(neural cell adhesion molecule, NCAM)在ACC中的表达, 探讨S-100和NCAM与ACC嗜神经侵袭性的关系。
方法对天津医科大学口腔医院42例ACC病例应用免疫组织化学方法检测S-100和NCAM在ACC中的表达, 并探讨其相关性。
结果 S-100在ACC嗜神经组阳性表达率80.0%明显高于非嗜神经组33.3%(P=0.011)。NCAM在嗜神经和非嗜神经侵袭组ACC中的阳性表达差异无统计学意义。S-100与NCAM在ACC中的阳性表达无明显相关性(P > 0.05)。
结论 S-100蛋白的表达与ACC的嗜神经现象密切相关, 在管状型中的表达明显高于充实型, 与肿瘤细胞分化具有一定相关性。NCAM蛋白的表达与ACC的嗜神经现象无统计学相关性, 与S-100蛋白的表达亦无明显相关。

Abstract:
Objectives To analyze the clinicopathologic features of adenoid cystic carcinoma(ACC), the expression of S-100 and neural cell adhesion molecule(NCAM) was investigated in ACC, and the relationship between S-100 and NCAM in ACC with perineural invasion was discussed.
Methods The S-100 and NCAM expression in 42 ACC cases was determined using inimunohistochemistry, and the relationship between them was discussed.
Results The rate of S-100 expression was 80%in the neural invasion group, which is significantly higher compared to the non-neural invasion group(33.3%)(P = 0.011, P < 0.05).The difference in NCAM positive expression between the neural invasion group and the non-neural invasion group was not statistically significant.S-100 and NCAM expression was not significantly different(P > 0.05).
Conclusion S-100 expression is closely correlated with neural invasion in ACC.and a significant difference in the tubular and solid subtypes is correlated with ACC cell differentiation.NCAM expression is not correlated with ACC neural invasion and S-100 expression.

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