Abstract:
Objectives To investigate the impact of neoadjuvant therapy on local advanced rectal cancer surgery in the perioperative and postoperative periods.
Methods The medical records of 34 patients who undenvent surgery after neoadjuvant therapy for local advanced rectal cancer(group A) and 146 patients who underwent surgery without neoadjuvant therapy at the same stage(group B) between January 2010 and December 2010 were retrospectively reviewed.
Results The tumor resection rates in groups A and B were 100%and 89%, the R0 resection rates were 97.1%and 82.9%, the sphincter-saving rates were 73.5%and 54.8%, and the perioperative complication rates were 5.9%and 4.8%, respectively.The average operation time, postoperative recovery time, and perioperative complication rate did not have significant statistical differences.In the follow-up after 1 year, the local recurrence and liver metastases in groups A and B were 0 vs.16 and 1 vs.5, respectively.
Conclusion Neoadjuvant therapy for local advanced rectal cancer does not increase the average operation time, postoperative recovery time, and perioperative complications.This therapy can also significantly improve the tumor resection, R0 resection, and sphincter-saving rates, as well as reduce the local recurrence rate.