Abstract: Brain is considered an uncommon metastatic site for epithelial ovarian cancer.The incidence has increased during the last two decades.Most patients suffer from headache as the disease relapses at brain.The diagnosis is based on CT or MRI results.Now there is no uniform therapy options.The multimodality treatment including neurosurgery, radiotherapy and chemotherapy benifit the patients with brain metastasis.Especially for those patiens with single metastases, neurosurgery combined with other treatments can improve prognosis. Then a prospect arises up with the application of stereotactic radiosurgery.The disease has a poor prognosis.Several prognostic factors are still being discussed today.But only a high performance status and the absence of an extra cranial disease at the time of CNS relapse have been accepted throughout the current literature as having a significant positive impact on survival.