Abstract: Breast cancer has become the first major female cancer that has increasingly threatened the health of women worldwide. The incidence of breast cancer has been reported to increase yearly.Thus, early diagnosis, individual treatment, and prognosis of breast cancer have currently been given more focus.Breast tumor biomarkers are significant guide for the early diagnosis, individual treatment, and prognosis of breast cancer.With the rapid development of molecular biology, very important foundations for basic and clinic research on breast cancer have been conducted.In recent years, various methods for the diagnosis and treatment of breast cancer have been proposed, and doctors who work in clinics daily have increasingly favored the use of breast tumor biomarkers.However, the use of classic tumor markers is insufficient in dealing with breast cancer.Thus, many studies constantly develop new biomarkers to improve the techniques for the treatment and therapy of breast cancer, to relieve the pain of patients with breast cancer, and to reduce the social and personal economic burden.This article discusses the new developments on breast tumor biomarkers.