Abstract:
Objective To determine the effect of the time interval between bilateral primary breast cancer(BPBC) on the concordance of hormone receptor and human epidermal growth factor receptor(HER)-2 expression and the prognosis.
Methods The medical records of 366 BPBC patients were reviewed.The patients were then grouped according to the time interval between the two cancers.Data analysis focused on the concordance of hormone receptor and HER-2 expression between the first and second primary breast cancers and the prognosis of BPBC in different groups.
Results There was a positive association between the hormone receptors and HER-2 of bilateral tumors.The strongest association was found in the group in which the time interval was≤12 months(P < 0.05).Although the concordance rate in the group with a time interval > 12 months was high, there was no statistical significance(P > 0.05).Patients with a time interval≤12 months had lower overall survival rates than those with a time interval > 12 months.
Conclusion The expression levels of estrogen receptor, progesterone receptor, and HER-2 in BPBC are greatly similar when the time interval is≤12 months.Patients' overall survival rate is also lower when the time interval is > 12 months.Synchronous and metachronous BPBC divided by 12 months can reflect the association and prognosis of bilateral cancers.