Effects of the Time Interval between Bilateral Primary Breast Cancer on the Prognosis and Concordance of Hormone Receptor and Human Epidermal Growth Factor Receptor-2 Expression
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摘要:
目的 分析两癌发生间隔时间对双侧原发性乳腺癌雌激素受体(ER)、孕激素受体(PR)及人表皮生长因子受体2(HER-2)表达一致性及预后的影响。 方法 回顾性分析366例双侧原发性乳腺癌(bilateral primarv breast cancer, BPBC)患者的病理资料, 按照两癌发生的间隔时间进行分组, 侧重分析不同组内第一原发癌与第二原发癌ER、PR、HER-2表达的一致性及两癌间隔时间对BPBC预后的影响。 结果 BPBC第一原发癌与第二原发癌的ER、PR、HER-2表达呈正相关, 两癌间隔时间≤12个月的BPBC双侧ER、PR、HER-2表达密切相关(P < 0.05), 而两癌间隔时间 > 12个月的BPBC双侧ER、PR、HER-2表达相关性无统计学意义(P > 0.05)两癌间隔时间≤12个月较 > 12个月发生者远期生存率低, 预后差。 结论 12个月内发生的BPBC两癌在ER、PR、HER-2表达方面具有较高的相似性, 远期生存率较低, 同异时性BPBC以12个月划分更能反映两癌之间的联系及预后。 -
关键词:
- 双侧原发性乳腺癌 /
- 雌激素受体 /
- 孕激素受体 /
- 人表皮生长因子受体2
Abstract:Objective To determine the effect of the time interval between bilateral primary breast cancer(BPBC) on the concordance of hormone receptor and human epidermal growth factor receptor(HER)-2 expression and the prognosis. Methods The medical records of 366 BPBC patients were reviewed.The patients were then grouped according to the time interval between the two cancers.Data analysis focused on the concordance of hormone receptor and HER-2 expression between the first and second primary breast cancers and the prognosis of BPBC in different groups. Results There was a positive association between the hormone receptors and HER-2 of bilateral tumors.The strongest association was found in the group in which the time interval was≤12 months(P < 0.05).Although the concordance rate in the group with a time interval > 12 months was high, there was no statistical significance(P > 0.05).Patients with a time interval≤12 months had lower overall survival rates than those with a time interval > 12 months. Conclusion The expression levels of estrogen receptor, progesterone receptor, and HER-2 in BPBC are greatly similar when the time interval is≤12 months.Patients' overall survival rate is also lower when the time interval is > 12 months.Synchronous and metachronous BPBC divided by 12 months can reflect the association and prognosis of bilateral cancers. -
Key words:
- Bilateral breast neoplasm /
- Estrogen receptors /
- Progesterone receptors /
- HER-2
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表 1 双侧原发性乳腺癌ER表达的相关性分析 例
Table 1. Association of estrogen receptor status between bilateral primary breast cancers
表 2 双侧原发性乳腺癌PR表达的相关性分析 例
Table 2. Association of progesterone receptor status between bilateral primary breast cancers
表 3 双侧原发性乳腺癌HER-2表达的相关性分析 例
Table 3. Association of HER-2 status between bilateral primary breast cancers
表 4 不同间隔时间双侧原发性乳腺癌的预后分析
Table 4. The prognosis of bilateral primary breast cancer patients with different time intervals
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[1] 吕明丽, 张晟, 刘红, 等. 双侧原发性乳腺癌ER、PR及HER-2表达特征及其与预后的关系[J]. 中华乳腺病杂志(电子版), 2009, 3(1): 19-23. [2] Coradini D, Oriana S, Mariani L, et al. Is steroid receptor profile in contralateral breast cancer a marker of independence of the corresponding primary tumour[J]? Eur J Cancer, 1998, 34(6): 825-830. [3] Gong SJ, Rha SY, Jeung HC, et al. Bilateral breast cancer: differential diagnosis using histological and biological parameters[J]. Jpn J Clin Oncol, 2007, 37(7): 487-492. doi: 10.1093/jjco/hym056 [4] Huo D, Melkonian S, Rathouz PJ, et al. Concordance in histological and biological parameters between first and second primary breast cancers[J]. Cancer, 2011, 117(5): 907-915. doi: 10.1002/cncr.25587 [5] Robbins GF, Berg JW. Bilateral primary breast cancer: a prospective clinicopathological study[J]. Cancer, 1964, 17: 1501-1527. [6] 阚秀, 主编. 乳腺癌临床病理学[M]. 北京: 北京医科大学出版社, 1993: 98-102. [7] 《乳腺癌HER2检测指南》编写组. 乳腺癌HER2榆测指南[J]. 中华病理学杂志, 2006, 35(10): 631-633. doi: 10.3760/j.issn:0529-5807.2006.10.015 [8] Kollias J, Pinder SE, Denley HE, et al. Phenotypic similarities in bilateral breast cancer[J]. Breast Cancer Res Treat, 2004, 85(3): 255-261. [9] Swain SM, Wilson JW, Mamounas EP, et al. Estrogen receptor status of primary breast cancer is predictive of estrogen receptor status of contralateral breast cancer[J]. J Natl Cancer Inst, 2004, 96(7): 516-523. [10] Vuoto HD, Garcia AM, Candas GB, et al. Bilateral breast carcinoma: clinical characteristics and its impact on survival[J]. Breast J, 2010, 16 (6): 625-632. doi: 10.1111/j.1524-4741.2010.00976.x [11] 张涛, 张保宁. 双侧原发性乳腺癌临床与预后分析[J]. 中华肿瘤杂志, 2004.26(12): 55-57. doi: 10.1111/j.1524-4741.2010.00976.x [12] Fisher ER, Fisher B, Sass R, et al. Pathologic findings from the National Surgical Adjuvant Breast Project(Protocol No. 4). XI. Bilateral breast cancer[J]. Cancer, 1984, 54(12): 3002-3011. doi: 10.1002/1097-0142(19841215)54:12<3002::AID-CNCR2820541231>3.0.CO;2-V [13] Kheirelseid EA, Jumustafa H, Miller N, et al. Bilateral breast cancer: analysis of incidence, outcome, survival and disease characteristics[J]. Breast Cancer Res Treat, 2011, 126(1): 131-140. doi: 10.1007/s10549-010-1057-y -
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