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摘要: 神经纤维瘤是来源于周围神经的良性肿瘤, 可发生于身体任何部位。神经纤维瘤伴多发钙化临床少见, 当其位于四肢软组织时极易误诊, 且临床症状及影像学表现无特征, 术前准确诊断较为困难本文回顾性分析天津医科大学附属肿瘤医院骨与软组织肿瘤科1例经手术切除且病理证实的神经纤维瘤伴多发钙化的临床特点及影像学表现, 同时结合相关文献, 对神经纤维瘤伴钙化病例进行整理分析, 以期初步探讨神经纤维瘤伴多发钙化的临床特征、影像学表现及鉴别诊断要点, 提高对本病的认识。Abstract: Neurofibroma is a benign tumor derived from the peripheral nerve and could occur in any part of the body.Neurofibroma with multiple calcifications is uncommon and is easily misdiagnosed.Accurate preoperative diagnosis for neurofibroma is difficult because of lack of clinical symptoms and imaging characteristics.This study aims to retrospectively analyze the clinical features and imaging performance of one neurofibroma case confirmed via surgery and pathology in the Department of Bone and Soft Tissue Tumor of our hospital. Related studies were reviewed to explore the clinical features, imaging findings, and differential diagnosis of neurofibroma with multiple calcifications and to improve the understanding of this disease.
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Key words:
- Neurofibroma /
- Calcification /
- Imaging
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图 1 MRI显示股骨后侧不规则多结节肿物，T1W1呈低信号，T2WI呈不均匀高信号
A：MRI T1W1矢状位；B：MRI T2WI冠状位
Figure 1. MRI shows irregular nodular tumor of the femur posterior: T1W1 at low signal and T2W1 at inhomogeneous high signal
图 2 神经纤维瘤组织病理学特点
：神经纤维瘤细胞梭长杆状，胞浆NSE阳性（IHC×200）；B：肿瘤细胞胞浆/胞核弥漫性表达S-100（IHC ×100）；C：肿瘤细胞间大量点状、片状钙化（H&E×100）
Figure 2. Histopathological characteristics of neurofibroma
表 1 神经纤维瘤伴钙化影像学特点
Table 1. Imaging characteristics of neurofibroma with calcification
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