Th17和FOXP3<sup>+</sup>T在胃黏膜相关淋巴组织淋巴瘤发病中的意义

陈广侠; 姜葵; 周璐; 徐东波; 王邦茂

doi:10.3969/j.issn.1000-8179.2012.12.005

Th17和FOXP3⁺T在胃黏膜相关淋巴组织淋巴瘤发病中的意义

doi: 10.3969/j.issn.1000-8179.2012.12.005

陈广侠^①,
姜葵^①, ,,
周璐^①,
徐东波^②,
王邦茂^①

①.
天津医科大学总医院消化内科（天津市300052）
②.
天津医科大学病理科

详细信息

通讯作者:
姜葵 jiangkui66@sohu.com

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出版历程
- 收稿日期: 2011-12-18
- 修回日期: 2012-06-05

Significance of Th17 and FOXP3⁺ Regulatory T Cells in Pathogenesis of Gastric Mucosa-Associated Lymphoid Tissue Lymphoma

Guangxia CHEN^①,
Kui JIANG^{①
, ,},
Lu ZHOU^①,
Dongbo XU^②,
Bangmao WANG^①

①.
Department of Gastroenterology, Tianjin Medical University General Hospital, Tianjin 300052, China
②.
Department of Pathology, Tianjin Medical University, Tianjin 300052, China

More Information

Corresponding author: Kui JIANG; E-mail: jiangkui66@sohu.com

摘要

摘要: 目的探讨Th17和FOXP3⁺T（Treg）阳性细胞在慢性胃炎、淋巴细胞性胃炎和胃黏膜相关淋巴组织（MALT）淋巴瘤中的意义。方法采用免疫组织化学方法检测18例慢性胃炎、17例淋巴细胞性胃炎和18例低度恶性胃MALT淋巴瘤组织中Th17及FOXP3⁺T细胞的表达情况。结果 Th17在慢性胃炎组、淋巴细胞性胃炎组和胃MALT淋巴瘤组阳性细胞数分别为（11.2±2.4）、（15.1±5.3）和（16.8±5.4）个/每高倍镜视野，胃MALT淋巴瘤与慢性胃炎相比，差别有统计学意义（P < 0.05），但胃MALT淋巴瘤与淋巴细胞性胃炎间差别无统计学意义（P>0.05）。FOXP3⁺T在慢性胃炎组、淋巴细胞性胃炎组和胃MALT淋巴瘤组的细胞数分别为（5.1±2.7）、（22.4±4.0）和（30.8±7.2）个/每高倍镜视野，三组间两两比较差异均有统计学意义（P < 0.05）。FOXP3⁺T和Th17细胞数量改变在胃MALT淋巴瘤组呈正相关（R=0.308，P < 0.05）。结论 FOXP3⁺T和Th17细胞数量在淋巴细胞性胃炎和胃MALT淋巴瘤组织中增多，可能在胃MALT淋巴瘤的发生、发展过程中发挥作用。
- Th17细胞 /
- FOXP3⁺调节T细胞 /
- 胃黏膜相关淋巴组织淋巴瘤 /
- 免疫组织化学
Abstract: Objective To investigate the role of Th17 and Treg in chronic gastritis, lymphocytic gastritis, and low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Methods The expression of FOXP3⁺Treg and Th17 in 18 chronic gastritis, 17 lymphocytic gastritis, and 18 gastric MALT lymphoma cases were detected by immunohistochemical staining. Results IL-17 expression increased in the chronic gastritis, lymphocytic gastritis, and gastric MALT lymphoma cases. However, no statistical significance was found in IL-17 expression between lymphocytic gastritis and gastric MALT lymphoma. The expression of FOXP3⁺Treg cells increased in the chronic gastritis, lymphocytic gastritis, and gastric MALT lymphoma cases (P < 0.05) (corresponding to 30.8 ± 7.2, 22.4 ± 4.0, and 5.1 ± 2.7 per high magnification field, respectively). The density of FOXP3⁺Treg cells was positively correlated with the expression of IL-17 (r = 0.308, P < 0.05). Conclusion Th17 and Treg may play certain roles in the development of gastric MALT lymphoma.
- Th17 cells /
- FOXP3⁺T /
- Gastric mucosa-associated lymphoid tissue lymphoma /
- Immunohistochemistry

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图 1 免疫组织化学染色IL-17在各组胃组织中的表达（×400）

A：慢性胃炎；B：淋巴细胞性胃炎；C：胃MALT淋巴瘤

Figure 1. Immunohistochemical staining for IL-17 expression in gastric mucosa

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图 2 FOXP3⁺在不同胃组织中的表达（×400）

A：慢性胃炎；B：淋巴细胞性胃炎；C：胃MALT淋巴瘤

Figure 2. Immunohistochemical staining for FOXP3⁺ expression in gastric mucosa

下载: 全尺寸图片幻灯片

表 1 53例病例的临床资料

Table 1. Clinical data of 53 patients

表 2 IL-17和FOXP3⁺在胃MALT淋巴瘤、淋巴细胞性胃炎和慢性胃炎组织中的表达

Table 2. IL-17 and FOXP3⁺ expression in gastric MALT lymphoma, lymphocytic gastritis, and chronic gastritis

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