Abstract:
Objective To observe the expression and clinical significance of Bmi-l protein in esophageal squamous cell carcinoma (ESCC) and to discuss the correlation between the Bmi-l expression and ESCC.
Methods The expression of Bmi-l protein in 168 cases with the ESCC tissue and 30 with normal esophageal mucosa was determined through immunohistochemistry.
Results The expression rates of Bmi-l were 66.1% (111/168) and 23.3% (7/30) in the ESCC tissues and normal esophageal mucosa, respectively. Statistically significant differences were observed in the positive expression of Bmi-l between the ESCC and the normal mucosal tissues of the esophagus (P < 0.001). The positive expression of Bmi-l in ESCC has been found to be related to the histological differentiation, TNM stages, and lymphatic metastases (P= 0.016, P= 0.004, and P= 0.001). Moreover, the 5-year survival was superior in the Bmi-l-negative group than that in the Bmi-l-positive group (P < 0.001).
Conclusion Bmi-l may play an important role in oncogenesis and progression of ESCC. Detection of the Bmi-l expression is important in evaluating the prognosis of ESCC.